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Home / Publicações / ECIL guidelines for preventing Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients

ECIL guidelines for preventing Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients

  • Autores: 5th European Conference on Infections in Leukaemia (ECIL-5), a joint venture of The European Group for Blood and Marrow Transplantation (EBMT), Alanio A, Bretagne S, Cesaro S, Cordonnier C, Donnelly JP, Einsele H, Hauser PM, Helweg-Larsen J, Lagrou K, Maertens J, Maschmeyer G, Matos O, Melchers WJ, the European LeukemiaNet (ELN), The European Organization for Research and Treatment of Cancer (EORTC), the Immunocompromised Host Society (ICHS)
  • Ano de Publicação: 2016
  • Journal: Journal of Antimicrobial Chemotherapy
  • Link: https://academic.oup.com/jac/article/71/9/2397/2237828

The 5th European Conference on Infections in Leukaemia (ECIL-5) meeting aimed to establish evidence-based recommendations for the prophylaxis of Pneumocystis jirovecii pneumonia (PCP) in non-HIV-infected patients with an underlying haematological condition, including allogeneic HSCT recipients. Recommendations were based on the grading system of the IDSA. Trimethoprim/sulfamethoxazole given 2-3 times weekly is the drug of choice for the primary prophylaxis of PCP in adults ( A-II: ) and children ( A-I: ) and should be given during the entire period at risk. Recent data indicate that children may benefit equally from a once-weekly regimen ( B-II: ). All other drugs, including pentamidine, atovaquone and dapsone, are considered second-line alternatives when trimethoprim/sulfamethoxazole is poorly tolerated or contraindicated. The main indications of PCP prophylaxis are ALL, allogeneic HSCT, treatment with alemtuzumab, fludarabine/cyclophosphamide/rituximab combinations, >4 weeks of treatment with corticosteroids and well-defined primary immune deficiencies in children. Additional indications are proposed depending on the treatment regimen.

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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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