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Home / Archives for Einsele H

Pneumocystis jirovecii pneumonia: Still a concern in patients with haematological malignancies and stem cell transplant recipients-authors’ response

  • Autores: a joint venture of The European Group for Blood and Marrow Transplantation (EBMT), Alanio A, Bretagne S, Cesaro S, Cordonnier C, Donnelly JP, Einsele H, Fifth European Conference on Infections in Leukemia (ECIL-5), Hauser PM, Helweg-Larsen J, Lagrou K, Maertens J, Maschmeyer G, Matos O, Melchers WJ, the European LeukemiaNet (ELN), The European Organization for Research and Treatment of Cancer (EORTC), the Immunocompromised Host Society (ICHS)
  • Ano de Publicação: 2017
  • Journal: Journal of Antimicrobial Chemotherapy
  • Link: https://academic.oup.com/jac/article/72/4/1266/2957000%20

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ECIL guidelines for the diagnosis of Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients

  • Autores: 5th European Conference on Infections in Leukaemia (ECIL-5), a joint venture of The European Group for Blood and Marrow Transplantation (EBMT), Alanio A, Bretagne S, Cesaro S, Cordonnier C, Donnelly JP, Einsele H, Hauser PM, Helweg-Larsen J, Lagrou K, Maertens J, Maschmeyer G, Matos O, Melchers WJ, The European Organization for Research and Treatment of Cancer (EORTC), the European LeukemiaNet (ELN), the Immunocompromised Host Society (ICHS)
  • Ano de Publicação: 2016
  • Journal: Journal of Antimicrobial Chemotherapy
  • Link: https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dkw156

The Fifth European Conference on Infections in Leukaemia (ECIL-5) convened a meeting to establish evidence-based recommendations for using tests to diagnose Pneumocystis jirovecii pneumonia (PCP) in adult patients with haematological malignancies. Immunofluorescence assays are recommended as the most sensitive microscopic method (recommendation A-II: ). Real-time PCR is recommended for the routine diagnosis of PCP ( […]
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ECIL guidelines for preventing Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients

  • Autores: 5th European Conference on Infections in Leukaemia (ECIL-5), a joint venture of The European Group for Blood and Marrow Transplantation (EBMT), Alanio A, Bretagne S, Cesaro S, Cordonnier C, Donnelly JP, Einsele H, Hauser PM, Helweg-Larsen J, Lagrou K, Maertens J, Maschmeyer G, Matos O, Melchers WJ, the European LeukemiaNet (ELN), The European Organization for Research and Treatment of Cancer (EORTC), the Immunocompromised Host Society (ICHS)
  • Ano de Publicação: 2016
  • Journal: Journal of Antimicrobial Chemotherapy
  • Link: https://academic.oup.com/jac/article/71/9/2397/2237828

The 5th European Conference on Infections in Leukaemia (ECIL-5) meeting aimed to establish evidence-based recommendations for the prophylaxis of Pneumocystis jirovecii pneumonia (PCP) in non-HIV-infected patients with an underlying haematological condition, including allogeneic HSCT recipients. Recommendations were based on the grading system of the IDSA. Trimethoprim/sulfamethoxazole given 2-3 times weekly is the drug of choice […]
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Pneumocystis jirovecii pneumonia: still a concern in patients with haematological malignancies and stem cell transplant recipients

  • Autores: Alanio A, Bretagne S, Cesaro S, Cordonnier C, Donnelly JP, Einsele H, Hauser PM, Helweg-Larsen J, Lagrou K, Maertens J; Fifth European Conference on Infections in Leukemia (ECIL-5), Maschmeyer G, Matos O, Melchers WJ, The European Organization for Research and Treatment of Cancer (EORTC), the European LeukemiaNet (ELN), the Immunocompromised Host Society (ICHS)
  • Journal: Journal of Antimicrobial Chemotherapy
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/27550990

Pneumocystis jirovecii can cause life-threatening pneumonia following treatment for haematological malignancies or after HSCT. The mortality rate of P. jirovecii pneumonia (PCP) in these patients is 30%-60%, especially after HSCT. The clinical presentation of PCP in haematology differs from that associated with HIV infection, with the disease being acute and more often severe, having a lower fungal burden and being more frequently linked to treatment with corticosteroids.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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