GHTM

Global Health and Tropical Medicine

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Home / Archives for Quintas A

Potent and broadly reactive HIV-2 neutralizing antibodies elicited by a vaccinia virus vector prime-C2V3C3 polypeptide boost immunization strategy

  • Authors: Barroso H, Borrego P, Marcelino JM, Novo C, Quintas A, Rocha C, Taveira N
  • Journal: Journal of Virology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Potent+and+broadly+reactive+HIV-2+neutralizing+antibodies+elicited+by+a+vaccinia+vector-prime

Human immunodeficiency virus type 2 (HIV-2) infection affects about 1 to 2 million individuals, the majority living in West Africa, Europe, and India. As for HIV-1, new strategies for the prevention of HIV-2 infection are needed. Our aim was to produce new vaccine immunogens that elicit the production of broadly reactive HIV-2 neutralizing antibodies (NAbs). […]
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Evolution of the human immunodeficiency virus type 2 envelope in the first years of infection is associated with the dynamics of the neutralizing antibody response

  • Authors: Barroso H, Bártolo I, Borrego P, Calado R, Cavaco-Silva P, Família C, Gomes P, Leitner T, Marcelino JM, Quintas A, Rocha C, Rosado L, Skar H, Taveira N
  • Journal: Retrovirology
  • Link: http://www.retrovirology.com/content/10/1/110

Differently from HIV-1, HIV-2 disease progression usually takes decades without antiretroviral therapy and the majority of HIV-2 infected individuals survive as elite controllers with normal CD4+ T cell counts and low or undetectable plasma viral load. Neutralizing antibodies (Nabs) are thought to play a central role in HIV-2 evolution and pathogenesis. However, the dynamic of the Nab response and resulting HIV-2 escape during acute infection and their impact in HIV-2 evolution and disease progression remain largely unknown. Our objective was to characterize the Nab response and the molecular and phenotypic evolution of HIV-2 in association with Nab escape in the first years of infection in two children infected at birth.
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An ancestral HIV-2/simian immunodeficiency virus peptide with potent HIV-1 and HIV-2 fusion inhibitor activity

  • Authors: Barroso H, Borrego P, Calado R, Marcelino JM, Pereira P, Quintas A, Taveira N
  • Journal: AIDS
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23324659

To produce new fusion inhibitor peptides for HIV-1 and HIV-2 based on ancestral envelope sequences.
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Resistance to antibody neutralization in HIV-2 infection occurs in late stage disease and is associated with X4 tropism.

  • Authors: Antunes F, Barroso H, Borrego P, Doroana M, Família C, Maltez F, Marcelino JM, Nilsson C, Quintas A, Taveira N
  • Journal: AIDS
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Resistance+to+antibody+neutralization+in+HIV-2+infection+occurs+in+late+stage+disease+and+is+associated+with+X4+tropism

OBJECTIVES:
To characterize the nature and dynamics of the neutralizing antibody (NAb) response and escape in chronically HIV-2 infected patients.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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