GHTM

Global Health and Tropical Medicine

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Home / Archives for Calado R

Ten years since the 2008 introduction of dental vouchers in the Portuguese NHS

  • Authors: Simões J, Figueiredo Augusto G, do Céu A, Ferreira MC, Jordão M, Calado R, Fronteira I
  • Publication Year: 2018
  • Journal: Health Policy
  • Link: https://www.sciencedirect.com/science/article/pii/S0168851018302756

Since the creation of the National Health Service (NHS) in Portugal, in 1979, dental care is neither provided nor funded by the NHS. Thus, most dental care is paid through out-of-pocket payments, either by patients themselves or through voluntary health insurance or health subsystems. In 2008 the government created the dental voucher targeting children, pregnant […]
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Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

  • Authors: Borrego P, Calado R, Duarte J, Marcelino JM, Rocha C, Sousa AE, Taveira N, Tendeiro R, Valadas E
  • Publication Year: 2017
  • Journal: AIDS
  • Link: https://insights.ovid.com/crossref?an=00002030-201711130-00014

Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. The authors found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 […]
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Evolution of the human immunodeficiency virus type 2 envelope in the first years of infection is associated with the dynamics of the neutralizing antibody response

  • Authors: Barroso H, Bártolo I, Borrego P, Calado R, Cavaco-Silva P, Família C, Gomes P, Leitner T, Marcelino JM, Quintas A, Rocha C, Rosado L, Skar H, Taveira N
  • Journal: Retrovirology
  • Link: http://www.retrovirology.com/content/10/1/110

Differently from HIV-1, HIV-2 disease progression usually takes decades without antiretroviral therapy and the majority of HIV-2 infected individuals survive as elite controllers with normal CD4+ T cell counts and low or undetectable plasma viral load. Neutralizing antibodies (Nabs) are thought to play a central role in HIV-2 evolution and pathogenesis. However, the dynamic of the Nab response and resulting HIV-2 escape during acute infection and their impact in HIV-2 evolution and disease progression remain largely unknown. Our objective was to characterize the Nab response and the molecular and phenotypic evolution of HIV-2 in association with Nab escape in the first years of infection in two children infected at birth.
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An ancestral HIV-2/simian immunodeficiency virus peptide with potent HIV-1 and HIV-2 fusion inhibitor activity

  • Authors: Barroso H, Borrego P, Calado R, Marcelino JM, Pereira P, Quintas A, Taveira N
  • Journal: AIDS
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23324659

To produce new fusion inhibitor peptides for HIV-1 and HIV-2 based on ancestral envelope sequences.
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Baseline susceptibility of primary HIV-2 to entry inhibitors.

  • Authors: Antunes F, Barroso H, Bártolo I, Borrego P, Caixas U, Calado R, Cavaco-Silva P, Doroana M, Maltez F, Marcelino JM, Rocha C, Taveira N
  • Journal: Antiviral Therapy
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Baseline+susceptibility+of+primary+HIV-2+to+entry+inhibitors

BACKGROUND:
The baseline susceptibility of primary HIV-2 to maraviroc (MVC) and other entry inhibitors is currently unknown.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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