- Autores: Borrego P, Calado R, Duarte J, Marcelino JM, Rocha C, Sousa AE, Taveira N, Tendeiro R, Valadas E
- Ano de Publicação: 2017
- Journal: AIDS
- Link: https://insights.ovid.com/crossref?an=00002030-201711130-00014
Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. The authors found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.