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Home / Archives for Leitner T

Accidental father-to-son HIV-1 transmission during the seroconversion period

  • Authors: Abecasis A, Bártolo I, Campos T, Ezeonwumelu IJ, Leitner T, Martin F, Romero-Severson EO, Taveira N
  • Publication Year: 2018
  • Journal: AIDS Research and Human Retroviruses
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30073842

A 4-year-old child born to an HIV-1 seronegative mother was diagnosed with HIV-1, the main risk factor being transmission from the child’s father who was seroconverting at the time of the child’s birth. In the context of a forensic investigation, we aimed to identify the source of infection of the child and date of the […]
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Donor-Recipient Identification in Para- and Poly-phyletic Trees Under Alternative HIV-1 Transmission Hypotheses Using Approximate Bayesian Computation

  • Authors: Abecasis A, Azevedo-Pereira JM, Bártolo I, Bulla I, Hengartner N, Leitner T, Romero-Severson EO, Taveira N
  • Publication Year: 2017
  • Journal: Genetics

Diversity of the founding population of Human Immunodeficiency Virus Type 1 (HIV-1) transmissions raises many important biological, clinical, and epidemiological issues. In up to 40% of sexual infections, there is clear evidence for multiple founding variants. These variants can influence the efficacy of putative prevention methods, and the reconstruction of epidemiologic histories. The authors created an […]
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On the contribution of Angola to the initial spread of HIV-1

  • Authors: Abecasis AB, Bártolo I, Leitner T, Pineda-Peña AC, Sousa JD, Taveira N, Theys K, Vandamme AM, Varanda J
  • Publication Year: 2016
  • Journal: Infection Genetics and Evolution
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/27521160

Angola borders and has long-term links with Democratic Republic of Congo (DRC) as well as high levels of Human Immunodeficiency Virus (HIV) genetic diversity, indicating a potential role in the initial spread of the HIV-1 pandemic. Herein, we analyze 564 C2V3 and 354 pol publicly available sequences from DRC, Republic of Congo (RC) and Angola […]
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Evolution of the human immunodeficiency virus type 2 envelope in the first years of infection is associated with the dynamics of the neutralizing antibody response

  • Authors: Barroso H, Bártolo I, Borrego P, Calado R, Cavaco-Silva P, Família C, Gomes P, Leitner T, Marcelino JM, Quintas A, Rocha C, Rosado L, Skar H, Taveira N
  • Journal: Retrovirology
  • Link: http://www.retrovirology.com/content/10/1/110

Differently from HIV-1, HIV-2 disease progression usually takes decades without antiretroviral therapy and the majority of HIV-2 infected individuals survive as elite controllers with normal CD4+ T cell counts and low or undetectable plasma viral load. Neutralizing antibodies (Nabs) are thought to play a central role in HIV-2 evolution and pathogenesis. However, the dynamic of the Nab response and resulting HIV-2 escape during acute infection and their impact in HIV-2 evolution and disease progression remain largely unknown. Our objective was to characterize the Nab response and the molecular and phenotypic evolution of HIV-2 in association with Nab escape in the first years of infection in two children infected at birth.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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