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Home / Archives for 2013

Programmes and calls for public health research in European countries

  • Authors: Barnhoorn F, Conceição C, Grimaud O, Katreniakova Z, McCarthy M, Narkauskaité L, Saliba A, Sammut M
  • Publication Year: 2013
  • Journal: European Journal of Public Health
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/24189793

Public health research, at population and organizational level, needs to be identified independently within ‘health’ research from biomedicine and life sciences. In PHIRE (Public Health Innovation and Research in Europe), we investigated the extent and character of public health research calls and programmes in European countries.
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Cell phenotypic change due to Cryptosporidium parvum infection in immunocompetent mice

  • Authors: Borrego M, Codices V, de Sousa B, Lopes A, Martins C, Matos O, Novo C, Pinho M
  • Publication Year: 2013
  • Journal: Acta Parasitologica
  • Link: http://link.springer.com/article/10.2478%2Fs11686-013-0113-2

Cryptosporidium parvum is an intracellular parasite causing enteritis which can become life-threatening in immunocompromised host. Immunoregulatory T cells play a central role in the regulatory network of the host. Here, we proposed to characterize the populations of immune cells during infection and reinfection with C. parvum. Four-week-old BALB/C mice were inoculated with oocysts of C. parvum at days 0 and 22.
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Dynamics of cytokines and immunoglobulins serum profiles in primary and secondary Cryptosporidium parvum infection: Usefulness of Luminex® xMAP technology

  • Authors: Borrego M, Codices V, de Sousa B, Lopes T, Martins C, Matos O, Novo C
  • Publication Year: 2013
  • Journal: Experimental Parasitology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23178641

Infection by Cryptosporidium parvum triggers a complex array of innate and adaptive cell mediated immune response, playing an important role in controlling the infection. To date, there are no studies applying the Luminex® xMAP technology to determine profiles of cytokines and immunoglobulins in the context of an infection by C. parvum. In this study, we analyzed these immune mediators in the serum of immunocompetent mice inoculated with C. parvum oocysts, using Luminex, to understand how the immune system responds to an infection by this parasite.
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Antiretroviral drug resistance in HIV-1 therapy-naive patients in Cuba

  • Authors: Abrahantes Y, Aleman Y, Alvarez A, Álvarez D, Aragonés C, Beheydt G, Campos J, Correa C, Dekeersmaeker N, Fonseca C, Imbrechts S, Kourí V, Martínez O, Perez J, Perez L, Schrooten Y, Soto Y, Van Laethem K, Vandamme AM, Vinken L
  • Publication Year: 2013
  • Journal: Infection Genetics and Evolution
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23416260

In Cuba, antiretroviral therapy rollout started in 2001 and antiretroviral therapy coverage has reached almost 40% since then. The objectives of this study were therefore to analyze subtype distribution, and level and patterns of drug resistance in therapy-naive HIV-1 patients.
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In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon

  • Authors: Alecrim MG, Brasil LW, Chehuan YF, Costa JS, Costa MR, Lacerda MV, Melo GC, Monteiro WM, Nogueira F, Silveira H
  • Publication Year: 2013
  • Journal: Malaria Journal
  • Link: http://www.malariajournal.com/content/12/1/226

Chloroquine (CQ) and primaquine (PQ) are still the drugs of choice to treat Plasmodium vivax malaria in many endemic areas, Brazil included. There is in vivo evidence for the P. vivax resistance to CQ in the Brazilian Amazon, where the increase in the proportion of P. vivax malaria parallels the increase of unusual clinical complications related to this species. In this study, in vitro CQ and mefloquine (MQ)-susceptibility of P. vivax isolates from the Western Brazilian Amazon was tested using the double-site enzyme-linked lactate dehydrogenase immunodetection (DELI) assay.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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