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Home / Archives for 2021

VLP-Based Vaccines as a Suitable Technology to Target Trypanosomatid Diseases

  • Autores: Aline Maria Vasconcelos Queiroz, Johny Wysllas de Freitas Oliveira, Cláudia Jassica Moreno, Diego M.A.Guérin, Marcelo Sousa-Silva
  • Ano de Publicação: 2021
  • Journal: Vaccines, 9(3), art 220, [Special Issue: Host Immune Response to Infectious Diseases pp 1 - 9]
  • Link: https://doi.org/10.3390/vaccines9030220

ABSTRACT Research on vaccines against trypanosomatids, a family of protozoa that cause neglected tropical diseases, such as Chagas disease, leishmaniasis, and sleeping sickness, is a current need. Today, according to modern vaccinology, virus-like particle (VLP) technology is involved in many vaccines, including those undergoing studies related to COVID-19. The potential use of VLPs as vaccine […]
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Virological screening of wild and farmed fish species: Application of innovative Taqman multiplex real-time PCR protocols

  • Autores: Andreia Filipa-Silva, Ricardo Parreira, Mónica Nunes, Maria Teresa Barreto Crespo
  • Ano de Publicação: 2021
  • Journal: Aquaculture, vol 54015, art 736693
  • Link: https://doi.org/10.1016/j.aquaculture.2021.736693

ABSTRACT Global demand for seafood is growing and fish stock maintenance becomes a pressing issue, making aquaculture production of capital importance in terms of fish resources sustainability. Therefore, fish disease outbreaks are a significant constraint to fisheries trade and aquaculture production, affecting economic development worldwide. In this study, a virological screening in wild and farmed fish […]
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Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity

  • Autores: Tatyana Almeida Tavella, Noeli Soares Melo da Silva, Natalie Spillman, Ana Carolina Andrade Vitor Kayano, Gustavo Capatti Cassiano, Adrielle Ayumi Vasconcelos, Antônio Pedro Camargo, Djane Clarys Baia da Silva, Diana Fontinha, Luis Carlos Salazar Alvarez, Letícia Tiburcio Ferreira, Kaira Cristina Peralis Tomaz, Bruno Junior Neves, Ludimila Dias Almeida, Daniel Youssef Bargieri, Marcus Vinicius Guimarães de Lacerda, Pedro Vítor Lemos Cravo, Per Sunnerhagen, Miguel Prudêncio, Carolina Horta Andrade, Stefanie Costa Pinto Lopes, Marcelo Falsarella Carazzolle, Leann Tilley, Elizabeth Bilsland, Júlio César Borges, Fabio Trindade Maranhão Costa
  • Ano de Publicação: 2021
  • Journal: ACS Infectious Diseases, 7(4), pp 759 - 7769
  • Link: https://doi.org/10.1021/acsinfecdis.0c00454

ABSTRACT Antimalarial drugs with novel modes of action and wide therapeutic potential are needed to pave the way for malaria eradication. Violacein is a natural compound known for its biological activity against cancer cells and several pathogens, including the malaria parasite, Plasmodium falciparum (Pf). Herein, using chemical genomic profiling (CGP), we found that violacein affects protein […]
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Utilization of a local ‘Malaria Post’ indicates that carers from a village in Mozambique respond appropriately to malaria attacks

  • Autores: Jacques D Charlwood, Erzelia V E Tomás, Sonia Enosse, Sara P Saija, Jannick Sahlholdt, Lourenço Filemon, Ayubo Kampango
  • Ano de Publicação: 2021
  • Journal: Acta Tropica, vol 221, art 106017
  • Link: https://doi.org/10.1016/j.actatropica.2021.106017

ABSTRACT As malaria elimination becomes a possibility the focus of interventions changes from vector control to disease control. It is important that treatment occurs early during an infection in order for it to be efficacious, especially at the population level. The time between the onset of symptoms and treatment seeking is, therefore, crucial. Following a […]
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Typhoid fever infection – Antibiotic resistance and vaccination strategies: A narrative review

  • Autores: Cristina Masuet-Aumatell, Jorge Atouguia
  • Ano de Publicação: 2021
  • Journal: Travel Medicine and Infectious Disease, vol 40, art 101946
  • Link: https://doi.org/10.1016/j.tmaid.2020.101946

ABSTRACT Typhoid fever is a bacterial infection caused by the Gram-negative bacterium Salmonella enterica subspecies enterica serovar Typhi (S. Typhi), prevalent in many low- and middle-income countries. In high-income territories, typhoid fever is predominantly travel-related, consequent to travel in typhoid-endemic regions; however, data show that the level of typhoid vaccination in travellers is low. Successful management of typhoid fever using antibiotics […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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