GHTM

Global Health and Tropical Medicine

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Immunoproteomics of Plasmodium falciparum-infected red blood cell membrane fractions

Plasmodium falciparum The surface of infected red blood cells (iRBCs) has been widely investigated because of the molecular complexity and pathogenesis mechanisms involved. Asymptomatic individuals are important in the field. They can perpetuate transmission as natural reservoirs. However, this presents a challenge for diagnosing malaria because of their low levels of circulating parasites. Recent studies […]
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Endothelial Cell Culture Under Perfusion On A Polyester-Toner Microfluidic Device

This study presents an inexpensive and easy way to produce a microfluidic device that mimics a blood vessel, serving as a start point for cell culture under perfusion, cardiovascular research, and toxicological studies. Endpoint assays (i.e., MTT reduction and NO assays) were used and revealed that the components making up the microchip, which is made […]
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Activity of rifabutin and hemi-synthetic derivatives against Mycobacterium abscessus

BACKGROUND: Mycobacterium abscessus causes a wide range of clinical diseases that are difficult to treat. This microorganism is resistant not only to the classical antituberculosis agents but also to most of the antimicrobials that are currently available, resulting in limited therapeutic options and treatment failure. This scenario stresses the need to search for new drugs […]
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Genetic diversity of the African malaria vector Anopheles gambiae

The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes that transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, identifying over 50 million single nucleotide polymorphisms within the […]
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The use of a methodological framework in the implementation of evidence as part of nursing research

OBJECTIVE: to reflect on the potentials of the conceptual framework Promoting Action on Research Implementation in Health Services (PARIHS) to translate knowledge and implement evidences in health and nursing. METHOD: this reflection was based on the methodological framework proposed, its use in the international context of health and nursing research and the possibilities in the Brazilian context. […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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1349-008 Lisboa
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Funding

UID/04413/2025 - DOI: 10.54499/UID/04413/2025

UID/PRR/04413/2025 - DOI: 10.54499/UID/PRR/04413/2025

UID/PRR2/04413/2025 - DOI: 10.54499/UID/PRR2/04413/2025