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Home / Archives for da Silva PEA

The contribution of efflux pumps in mycobacterium abscessus complex resistance to clarithromycin

  • Authors: Vianna JS, Machado D, Ramis IB, Silva FP, Bierhals DV, Abril MA, von Groll A, Ramos DF, Lourenço MCS, Viveiros M, da Silva PEA
  • Publication Year: 2019
  • Journal: Antibiotics
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31540480

The basis of drug resistance in Mycobacterium abscessus is still poorly understood. Nevertheless, as seen in other microorganisms, the efflux of antimicrobials may also play a role in M. abscessus drug resistance. Here, we investigated the role of efflux pumps in clarithromycin resistance using nine clinical isolates of M. abscessus complex belonging to the T28 erm(41) sequevar responsible for the inducible resistance […]
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Antimicrobial and Efflux Inhibitor Activity of Usnic Acid Against Mycobacterium abscessus

  • Authors: Ramis IB, Vianna JS, Reis AJ, von Groll A, Ramos DF, Viveiros M, da Silva PEA
  • Publication Year: 2018
  • Journal: Planta Medica
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29913527

New drugs are needed to treat infections with antimicrobial-resistant Mycobacterium abscessus; therefore, we evaluated usnic acid as an antimicrobial agent and efflux inhibitor (EI) against M. abscessus. Usnic acid showed antimicrobial activity, and synergistically, the EI verapamil increased this activity. In addition, when we evaluated the interaction of antimicrobials with usnic acid, the increase of their activity was […]
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Activity of rifabutin and hemi-synthetic derivatives against Mycobacterium abscessus

  • Authors: da Silva PEA, do Ceu Costa M, Figueiredo R, Halicki PCB, Ramis IB, Ramos DF, Viveiros M, von Groll A
  • Publication Year: 2017
  • Journal: Medicinal Chemistry
  • Link: http://www.eurekaselect.com/158037/article

BACKGROUND: Mycobacterium abscessus causes a wide range of clinical diseases that are difficult to treat. This microorganism is resistant not only to the classical antituberculosis agents but also to most of the antimicrobials that are currently available, resulting in limited therapeutic options and treatment failure. This scenario stresses the need to search for new drugs […]
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An Experimental Model for the Rapid Screening of Compounds with Potential Use Against Mycobacteria

  • Authors: Azzali E, Coelho T, Costa SS, Couto I, da Silva PEA, Lopes E, Machado D, Pieroni M, Viveiros M
  • Publication Year: 2016
  • Journal: ASSAY and Drug Development Technologies
  • Link: https://www.liebertpub.com/doi/pdf/10.1089/adt.2016.752

Infections caused by Mycobacterium tuberculosis and other mycobacteria are major challenges for global public health. Particularly worrisome are infections caused by multidrug-resistant bacteria, which are increasingly difficult to treat because of the loss of efficacy of the current antibacterial agents, a problem that continues to escalate worldwide. There has been a limited interest and investment […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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