GHTM

Global Health and Tropical Medicine

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Home / Archives for Antibiotics

Phenotypic and Molecular Traits of Staphylococcus coagulans Associated with Canine Skin Infections in Portugal

  • Authors: Sofia Santos Costa, Valéria Oliveira, Maria Serrano, Constança Pomba, Isabel Couto
  • Publication Year: 2021
  • Journal: Antibiotics, 10(5), art 518
  • Link: https://doi.org/10.3390/antibiotics10050518

Antibiotics 2021, 10(5), 518;
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The contribution of efflux pumps in mycobacterium abscessus complex resistance to clarithromycin

  • Authors: Vianna JS, Machado D, Ramis IB, Silva FP, Bierhals DV, Abril MA, von Groll A, Ramos DF, Lourenço MCS, Viveiros M, da Silva PEA
  • Publication Year: 2019
  • Journal: Antibiotics
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31540480

The basis of drug resistance in Mycobacterium abscessus is still poorly understood. Nevertheless, as seen in other microorganisms, the efflux of antimicrobials may also play a role in M. abscessus drug resistance. Here, we investigated the role of efflux pumps in clarithromycin resistance using nine clinical isolates of M. abscessus complex belonging to the T28 erm(41) sequevar responsible for the inducible resistance […]
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Efflux Activity Differentially Modulates the Levels of Isoniazid and Rifampicin Resistance among Multidrug Resistant and Monoresistant Mycobacterium tuberculosis Strains

  • Authors: Machado D, Perdigão J, Portugal I, Pieroni M, Silva PA, Couto I, Viveiros M
  • Publication Year: 2018
  • Journal: Antibiotics
  • Link: http://www.mdpi.com/2079-6382/7/1/18/htm

With the growing body of knowledge on the contribution of efflux activity toMycobacterium tuberculosisdrug resistance, increased attention has been given to the use of efflux inhibitors as adjuvants of tuberculosis therapy. Here, we investigated how efflux activity modulates the levels of efflux between monoresistant and multi- and extensively drug resistant (M/XDR)M. tuberculosisclinical isolates. The strains […]
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A non-antibiotic drug highly effective, in combination with first line anti-tuberculosis drugs, against any form of antibiotic resistance of Mycobacterium tuberculosis due to its multi-mechanisms of action

  • Authors: Amaral L, Viveiros M
  • Publication Year: 2017
  • Journal: Antibiotics
  • Link: http://www.mdpi.com/2079-6382/6/1/3

This review presents the evidence that supports the use of thioridazine (TZ) for the therapy of a pulmonary tuberculosis infection regardless of its antibiotic resistance status. The evidence consists of in vitro and ex vivo assays that demonstrate the activity of TZ against all encountered Mycobacterium tuberculosis (Mtb) regardless of its antibiotic resistance phenotype, as well as […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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+351 213 652 600

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