An Experimental Model for the Rapid Screening of Compounds with Potential Use Against Mycobacteria

Infections caused by Mycobacterium tuberculosis and other mycobacteria are major challenges for global public health. Particularly worrisome are infections caused by multidrug-resistant bacteria, which are increasingly difficult to treat because of the loss of efficacy of the current antibacterial agents, a problem that continues to escalate worldwide. There has been a limited interest and investment […]
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Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil

Authors: Coelho T, Couto I, Machado D, Maschmann R, Ramos D, Rossetti ML, Silva PA, Viveiros M, von Groll A
Publication Year: 2015
Journal: Frontiers in Microbiology
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412083/%20

Drug resistant tuberculosis continues to increase and new approaches for its treatment are necessary. The identification of M. tuberculosis clinical isolates presenting efflux as part of their resistant phenotype has a major impact in tuberculosis treatment. In this work, we used a checkerboard procedure combined with the tetrazolium microplate-based assay (TEMA) to study single combinations […]
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An Experimental Model for the Rapid Screening of Compounds with Potential Use Against Mycobacteria

Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil

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