GHTM

Global Health and Tropical Medicine

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Home / Archives for Coelho T

An Experimental Model for the Rapid Screening of Compounds with Potential Use Against Mycobacteria

  • Authors: Azzali E, Coelho T, Costa SS, Couto I, da Silva PEA, Lopes E, Machado D, Pieroni M, Viveiros M
  • Publication Year: 2016
  • Journal: ASSAY and Drug Development Technologies
  • Link: https://www.liebertpub.com/doi/pdf/10.1089/adt.2016.752

Infections caused by Mycobacterium tuberculosis and other mycobacteria are major challenges for global public health. Particularly worrisome are infections caused by multidrug-resistant bacteria, which are increasingly difficult to treat because of the loss of efficacy of the current antibacterial agents, a problem that continues to escalate worldwide. There has been a limited interest and investment […]
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Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil

  • Authors: Coelho T, Couto I, Machado D, Maschmann R, Ramos D, Rossetti ML, Silva PA, Viveiros M, von Groll A
  • Publication Year: 2015
  • Journal: Frontiers in Microbiology
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412083/%20

Drug resistant tuberculosis continues to increase and new approaches for its treatment are necessary. The identification of M. tuberculosis clinical isolates presenting efflux as part of their resistant phenotype has a major impact in tuberculosis treatment. In this work, we used a checkerboard procedure combined with the tetrazolium microplate-based assay (TEMA) to study single combinations […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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