Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium

Authors: Barreca ML, Cannalire R, Cecchetti V, Couto I, Felicetti T, Machado D, Manfroni G, Massari S, Sabatini S, Santos Costa S, Tabarrini O, Viveiros M
Publication Year: 2017
Journal: European Journal of Medicinal Chemistry
Link: https://www.ncbi.nlm.nih.gov/pubmed/28964936

Mycobacterium avium is a difficult-to-treat pathogen able to quickly develop drug resistance. Like for other microbial species, overexpression of efflux pumps is one of the main mechanisms in developing multidrug resistance. Although the use of efflux pumps inhibitors (EPIs) represents a promising strategy to reverse resistance, to date few M. avium EPIs are known. Recently, the […]
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Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

Authors: Borrego P, Calado R, Duarte J, Marcelino JM, Rocha C, Sousa AE, Taveira N, Tendeiro R, Valadas E
Publication Year: 2017
Journal: AIDS
Link: https://insights.ovid.com/crossref?an=00002030-201711130-00014

Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. The authors found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 […]
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The primary health care in the emirate of Abu Dhabi: are they aligned with the chronic care model elements?

Authors: Lapão LV, Loney T, Paulo MS
Publication Year: 2017
Journal: BMC Health Services Research
Link: https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-017-2691-4

Abu Dhabi is the capital of the United Arab Emirates (UAE) and the largest of the seven emirates in terms of land mass and population. Abu Dhabi emirate has three different geographical regions: the Central Capital District, the Eastern Region, and the Western Region. The health system has been regulated by the Health Authority – […]
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Cystoseira algae (Fucaceae): update on their chemical entities and biological activities

Authors: Bruno de Sousa C, Campino L, Gangadhar KN, Lago JH, Macridachis J, Morais TR, Pavão M, Varela J
Publication Year: 2017
Journal: Tetrahedron: Asymmetry
Link: https://www.sciencedirect.com/science/article/pii/S0957416617304664

Cystoseira (Sargassaceae) is a genus of marine brown algae composed of about 40 species, which is dis- tributed along the Eastern Atlantic and Mediterranean coasts. The biological potential of the Cystoseira genus has been investigated and several activities have been reported. Chemically, this genus contains a wide variety of secondary metabolites, such as terpenoids, steroids, […]
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Spatial risk of tuberculosis mortality and social vulnerability in Northeast Brazil

Authors: Alves LS, Arcêncio RA, Arroyo LH, Berra TZ, Chiaravalloti Neto F, Fronteira I, Garcia MCDC, Palha PF, Popolin MP, Queiroz AAR, Ramos ACV, Santos DTD, Yamamura M
Publication Year: 2017
Journal: Revista da Sociedade Brasileira de Medicina Tropical
Link: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000500693

Tuberculosis (TB) is the most common infectious disease in the world. The authors aimed to analyze the spatial risk of tuberculosis mortality and to verify associations in high-risk areas with social vulnerability. They performed an ecological study. In addition, they used scan statistic to detect areas at risk, and the Bivariate Moran Index to verify […]
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Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium

Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

The primary health care in the emirate of Abu Dhabi: are they aligned with the chronic care model elements?

Cystoseira algae (Fucaceae): update on their chemical entities and biological activities

Spatial risk of tuberculosis mortality and social vulnerability in Northeast Brazil

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