The experience of medical training and expectations about the future of medical practice of medical students at the University of Cape Verde

Authors: Degaldo AP, Ferrinho P, Martins AS
Publication Year: 2017
Journal: Acta Médica Portuguesa
Link: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/8179

Cape Verde is a small insular developing state. Its first experience of undergraduate medical education began in October 2015. The purpose of this paper is to describe and analyze the professional expectations and profile of the first class of medical students at the University of Cape Verde. A piloted, standardized questionnaire, with closed and open-ended questions, was […]
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Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance

Authors: Andres S, Aung HL, Beckert P, Clark TG, Coll F, Cook GM, Devi KRU, Diel R, Khumalo D, Klaos K, Kohl TA, Köser CU, Krause KL, Kumar SS, Machado D, Maphalala G, Merker M, Moradigaravand D, Nair D, Nakatani Y, Niemann S, Opel-Reading HK, Parkhill J, Peacock SJ, Perdigão J, Portugal I, Schön T, Swaminathan S, Viveiros M
Publication Year: 2017
Journal: Antimicrobial Agents and Chemotherapy
Link: https://www.ncbi.nlm.nih.gov/pubmed/28971867

A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d-cycloserine.
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Rotavirus A strains obtained from children with acute gastroenteritis in Mozambique, 2012-2013: G and P genotypes and phylogenetic analysis of VP7 and partial VP4 genes

Authors: Acácio S, Cassocera M, Cuamba A, de Deus N, João ED, Mandomando I, Motanyane L, O'Neill HG, Page N, Strydom A
Publication Year: 2017
Journal: Archives of Virology
Link: https://www.ncbi.nlm.nih.gov/pubmed/29052059

In Mozambique rotavirus (RV) was shown to be the greatest cause of acute diarrhoea in infants from 0 to 11 months, and in 2015, national rotavirus vaccination was introduced. As with other developing countries, there is very limited active strain characterisation. Rotavirus positive clinical specimens, collected between 2012 and 2013, have now provided information on the […]
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Implementation strategies to increase access and demand of long-lasting insecticidal nets a before-and-after study and scale-up process in Mozambique

Authors: Arroz JAH, Candrinho B, Martins MDRO, Mendis C, Pinto J, Pinto L
Publication Year: 2017
Journal: Malaria Journal
Link: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-017-2086-3

The universal coverage bed nets campaign is a proven health intervention promoting increased access, ownership, and use of bed nets to reduce malaria burden. This article describes the intervention and implementation strategies that Mozambique carried out recently in order to improve access and increase demand for long-lasting insecticidal nets (LLINs). A before-and-after study with a […]
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Insights on the mechanism of action of INH-C10 as an antitubercular prodrug

Authors: Leitão R, Loewen PC, Machado D, Machuqueiro M, Martins F, Ramos J, Switala J, Victor BL, Vila-Viçosa D
Publication Year: 2017
Journal: Molecular pharmaceutics
Link: https://www.ncbi.nlm.nih.gov/pubmed/29091448

Tuberculosis remains one of the top causes of death worldwide, and combating its spread has been severely complicated by the emergence of drug-resistance mutations, highlighting the need for more effective drugs. Despite the resistance to isoniazid (INH) arising from mutations in the katG gene encoding the catalase-peroxidase KatG, most notably the S315T mutation, this compound […]
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The experience of medical training and expectations about the future of medical practice of medical students at the University of Cape Verde

Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance

Rotavirus A strains obtained from children with acute gastroenteritis in Mozambique, 2012-2013: G and P genotypes and phylogenetic analysis of VP7 and partial VP4 genes

Implementation strategies to increase access and demand of long-lasting insecticidal nets a before-and-after study and scale-up process in Mozambique

Insights on the mechanism of action of INH-C10 as an antitubercular prodrug

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