Insights on the mechanism of action of INH-C10 as an antitubercular prodrug
- Authors: Leitão R, Loewen PC, Machado D, Machuqueiro M, Martins F, Ramos J, Switala J, Victor BL, Vila-Viçosa D
- Publication Year: 2017
- Journal: Molecular pharmaceutics
- Link: https://www.ncbi.nlm.nih.gov/pubmed/29091448
Tuberculosis remains one of the top causes of death worldwide, and combating its spread has been severely complicated by the emergence of drug-resistance mutations, highlighting the need for more effective drugs. Despite the resistance to isoniazid (INH) arising from mutations in the katG gene encoding the catalase-peroxidase KatG, most notably the S315T mutation, this compound […]
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