Chalcone derivatives: Promising starting points for drug design

Authors: Andrade CH, Cravo P, Gomes MN, Muratov EN, Neves BJ, Peixoto JC, Pereira M, Rosseto LP
Publication Year: 2017
Journal: Molecules
Link: http://www.mdpi.com/1420-3049/22/8/1210%20

Medicinal chemists continue to be fascinated by chalcone derivatives because of their simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a variety of promising biological activities. However, chalcones have still not garnered deserved attention, especially considering their high potential as chemical sources for designing and developing new effective drugs. In this review, we […]
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Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery

Authors: Azzali E, Cabassi CS, Costantino G, Flisi S, Kaushik A, Lamichhane G, Machado D, Pieroni M, Vacondio F, Viveiros M
Publication Year: 2017
Journal: Journal of Medicinal Chemistry
Link: https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b00793

Tuberculosis remains one of the deadliest infectious diseases in the world, and the increased number of multidrug-resistant and extremely drug-resistant strains is a significant reason for concern. This makes the discovery of novel antitubercular agents a cogent priority. We have previously addressed this need by reporting a series of substituted 2-aminothiazoles capable to inhibit the […]
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Migrant’s access to preventive health services in five EU countries

Authors: Buttigieg SC, Dauvrin M, Dias S, Ronda E, Rosano A, Tafforeau J
Publication Year: 2017
Journal: BMC Health Services Research
Link: https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-017-2549-9

Preventive health services (PHSs) form part of primary healthcare with the aim of screening to prevent disease. Migrants show significant differences in lifestyle, health beliefs and risk factors compared with the native populations. This can have a significant impact on migrants’ access to health systems and participation in prevention programmes. Even in countries with widely […]
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PhyloGeoTool: interactively exploring large phylogenies in an epidemiological context

Authors: Baele G, Bezenchek A, EucoHIV Study Group, Incardona F, Libin P, Nowé A, Sönnerborg A, Theys K, Vandamme AM, Vanden Eynden E
Publication Year: 2017
Journal: Bioinformatics
Link: https://www.ncbi.nlm.nih.gov/pubmed/28961923

MOTIVATION: Clinicians, health officials and researchers are interested in the epidemic spread of pathogens in both space and time to support the optimization of intervention measures and public health policies. Large sequence databases of virus sequences provide an interesting opportunity to study this spread through phylogenetic analysis. To infer knowledge from large phylogenetic trees, potentially […]
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Zika genomics urgently need standardized and curated reference sequences

Authors: Abecasis AB, Cuypers L, Dallmeier K, Libin P, Pineda-Peña AC, Theys K, Vandamme AM
Publication Year: 2017
Journal: PLoS Pathogens
Link: http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006528

Chalcone derivatives: Promising starting points for drug design

Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery

Migrant’s access to preventive health services in five EU countries

PhyloGeoTool: interactively exploring large phylogenies in an epidemiological context

Zika genomics urgently need standardized and curated reference sequences

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