GHTM

Global Health and Tropical Medicine

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Home / Archives for 2015

Gene expression changes in the salivary glands of Anopheles coluzzii elicited by Plasmodium berghei infection

  • Authors: Borges L, Cabezas-Cruz A, Coelho LP, de la Fuente J, Do Rosário V, Domingos A, Pinheiro-Silva R, Valdés JJ
  • Publication Year: 2015
  • Journal: Parasites & Vectors
  • Link: https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-015-1079-8%20

Malaria is a devastating infectious disease caused by Plasmodium parasites transmitted through the bites of infected Anopheles mosquitoes. Salivary glands are the only mosquito tissue invaded by Plasmodium sporozoites, being a key stage for the effective parasite transmission, making the study of Anopheles sialome highly relevant. RNA-sequencing was used to compare differential gene expression in […]
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Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals

  • Authors: Abecasis AB, Aerts J, Camacho RJ, Eusebio M, Gomes P, Portuguese HIVRSG, Suchard MA, Theys K, Vandamme AM, Winand R
  • Publication Year: 2015
  • Journal: AIDS
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570689/%20

Surveillance drug resistance mutations (SDRMs) in drug-naive patients are typically used to survey HIV-1-transmitted drug resistance (TDR). We test here how SDRMs in patients failing treatment, the original source of TDR, contribute to assessing TDR, transmissibility and transmission source of SDRMs. This is a retrospective observational study analyzing a Portuguese cohort of HIV-1-infected patients. The […]
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Spread of Leishmania infantum in Europe with dog travelling

  • Authors: Cardoso L, Maia C
  • Publication Year: 2015
  • Journal: Veterinary Parasitology
  • Link: https://www.sciencedirect.com/science/article/pii/S0304401715002393?via%3Dihub%20

Leishmania infantum is the etiological agent of canine leishmaniosis (CanL) in Europe, where it is endemic in the Mediterranean region, with dogs being considered the major reservoir of the parasite for humans and other mammalian hosts. The main transmission mode of Leishmania is by the bite of infected phlebotomine sand fly insects (genus Phlebotomus), which […]
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Evaluation of Antiplasmodial activity of extracts and constituents from Ampelozizyphus amazonicus

  • Authors: Amaral AC, do Carmo DF, Echevarria A, Lopes D, Machado M, Rosário VE, Silva JR
  • Publication Year: 2015
  • Journal: Pharmacognosy Magazine
  • Link: http://www.phcog.com/article.asp?issn=0973-1296;year=2015;volume=11;issue=44;spage=244;epage=250;aulast=do

Ampelozizyphus amazonicus Ducke, a plant that is widely used by the population of the Amazonian region to prevent and treat malaria, was investigated in this work, which describes, for the first time, the antiplasmodial activity of its extracts and associates this activity with its isolated constituents. Different extracts with solvents of increasing polarity (hexane, chloroform, […]
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Rotation of the external genitalia in male Phlebotomine sand flies (Diptera, Psychodidae) in laboratory conditions and in captured specimens in Algarve, Portugal

  • Authors: Afonso MO, Alves-Pires C, Campino L, Cristóvão JM, Ferrolho J, Gomes J, Maia C
  • Publication Year: 2015
  • Journal: Acta Tropica
  • Link: https://www.sciencedirect.com/science/article/pii/S0001706X15300383?via%3Dihub

Protozoal parasites are the causative agents of many insect-borne infectious diseases worldwide with impact on human and animal health. Leishmaniasis is caused by Leishmania spp. and transmitted by female Phlebotomine sand flies. In Portugal, two species of Phlebotomus (Larroussius), namely Phlebotomus perniciosus and Phlebotomus ariasi are the proven vectors of Leishmania infantum. Phlebotomine females and […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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Funding

UID/04413/2025 - DOI: 10.54499/UID/04413/2025

UID/PRR/04413/2025 - DOI: 10.54499/UID/PRR/04413/2025

UID/PRR2/04413/2025 - DOI: 10.54499/UID/PRR2/04413/2025

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