Prediction of response to antiretroviral therapy by human experts and by the EuResist data-driven expert system (the EVE study).
- Authors: Altmann A, Boucher CA, Brun-Vezinet F, Harrigan PR, Incardona F, Kaiser R, Lengauer T, Morris L, Obermeier M, Peres Y, Perno CF, Petroczi A, Phanuphak P, Pillay D, Prosperi M, Rosen-Zvi M, Schülter E, Shafer RW, Sönnerborg A, Struck D, Wensing AMJ, Zazzi M, Vandamme AM, Van Laethem K
- Journal: HIV Medicine
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Prediction+of+response+to+antiretroviral+therapy+by+human+experts+and+by+the+EuResist+data-driven+expert+system+(the+EVE+study).
OBJECTIVES:
The EuResist expert system is a novel data-driven online system for computing the probability of 8-week success for any given pair of HIV-1 genotype and combination antiretroviral therapy regimen plus optional patient information. The objective of this study was to compare the EuResist system vs. human experts (EVE) for the ability to predict response to treatment.
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Expected HIV-1 etravirine resistance after treatment failure with efavirenz and/or nevirapine
Antiretroviral drug resistance in HIV-1 therapy-naive patients in Cuba
- Authors: Abrahantes Y, Aleman Y, Alvarez A, Álvarez D, Aragonés C, Beheydt G, Campos J, Correa C, Dekeersmaeker N, Fonseca C, Imbrechts S, Kourí V, Martínez O, Perez J, Perez L, Schrooten Y, Soto Y, Van Laethem K, Vandamme AM, Vinken L
- Publication Year: 2013
- Journal: Infection Genetics and Evolution
- Link: http://www.ncbi.nlm.nih.gov/pubmed/23416260
In Cuba, antiretroviral therapy rollout started in 2001 and antiretroviral therapy coverage has reached almost 40% since then. The objectives of this study were therefore to analyze subtype distribution, and level and patterns of drug resistance in therapy-naive HIV-1 patients.
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Mutations selected in HIV-2-infected patients failing a regimen including atazanavir
- Authors: Aleixo MJ, Camacho RJ, Cavaco-Silva J, Cunha C, Faria D, Gomes P, Goncalves MF, Valadas E, Van Laethem K, Vandamme AM
- Journal: Journal of Antimicrobial Chemotherapy
- Link: http://www.ncbi.nlm.nih.gov/pubmed/22977160
To investigate mutations selected in viruses from HIV-2-infected patients failing a highly active antiretroviral treatment (HAART) regimen including atazanavir/ritonavir.
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