Prediction of response to antiretroviral therapy by human experts and by the EuResist data-driven expert system (the EVE study).

OBJECTIVES:
The EuResist expert system is a novel data-driven online system for computing the probability of 8-week success for any given pair of HIV-1 genotype and combination antiretroviral therapy regimen plus optional patient information. The objective of this study was to compare the EuResist system vs. human experts (EVE) for the ability to predict response to treatment.
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Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis

Authors: Aghokeng AF, Albert J, Avi R, Avila-Rios S, Bertagnolio S, Bessong PO, Blanco JL, Boucher CA, Brooks JI, Brumme ZL, Busch MP, Bussmann H, Chaix ML, Chin BS, D'Aquin TT, De Gascun CF, de Wit TR, Derache A, Descamps D, Deshpande AK, Djoko CF, Eshleman SH, Fleury H, Frange P, Fujisaki S, Hamers RL, Harrigan PR, Hattori J, Holguin A, Hunt GM, Ichimura H, Ioannidis JPA, Jordan MR, Kaleebu P, Katzenstein D, Kiertiburanakul S, Kim JH, Kim SS, Lemey P, Li Y, Lutsar I, Morris L, Ndembi N, Ng KP, Paranjape RS, Peeters M, Poljak M, Price MA, Ragonnet-Cronin ML, Reyes-Terán G, Rhee SY, Rolland M, Shafer RW, Sirivichayakul S, Smith DM, Soares MA, Soriano VV, Ssemwanga D, Stanojevic M, Stefani MA, Sugiura W, Sungkanuparph S, Tanuri A, Taylor J, Tee KK, Truong HM, Van de Vijver DA, Vandamme AM, Varghese V, Vidal N, Yang C, Yang R, Yebra G
Publication Year: 2015
Journal: Plos Medicine
Link: http://www.ncbi.nlm.nih.gov/pubmed/25849352

BACKGROUND: Regional and subtype-specific mutational patterns of HIV-1 transmitted drug resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines and designing diagnostic assays for use in regions where standard genotypic resistance testing is not affordable. We sought to understand the molecular epidemiology of TDR and to identify the HIV-1 drug-resistance mutations responsible for […]
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Clinical and virological response to antiretroviral drugs among HIV patients on first-line treatment in Dar-es-Salaam, Tanzania

Authors: Kasubi M, Ledwaba J, Morris L, Mosha F, Ndugulile F, Ng’ang’a Z, Nsubuga P, Swai A, Vandamme AM, Vercauteren J
Publication Year: 2014
Journal: The Journal of Infection in Developing Countries
Link: http://www.ncbi.nlm.nih.gov/pubmed/25022294

In Tanzania, the follow-up on antiretroviral therapy (ART) response is based on clinical outcomes. We investigated virological response and ARV resistance mutations in relation to clinical response in ARV-treated patients.
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Prediction of response to antiretroviral therapy by human experts and by the EuResist data-driven expert system (the EVE study).

Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis

Clinical and virological response to antiretroviral drugs among HIV patients on first-line treatment in Dar-es-Salaam, Tanzania

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