Structural modifications induced by specific HIV-1 protease-compensatory mutations have an impact on the virological response to a first-line lopinavir/ritonavir-containing regimen

Authors: Alcaro S, Alteri C, Antinori A, Artese A, Beheydt G, Bertoli A, Ceccherini-Silberstein F, Costa G, d’Arminio Monforte A, Girardi E, Gori C, Orchi N, Parrotta L, Perno CF, Santoro MM, Svicher V, Theys K, Vandamme AM
Publication Year: 2013
Journal: Journal of Antimicrobial Chemotherapy
Link: http://www.ncbi.nlm.nih.gov/pubmed/23687186

This study evaluates the impact of specific HIV-1 protease-compensatory mutations (wild-type amino acids in non-B subtypes) on virological response to a first-line lopinavir/ritonavir-containing regimen in an HIV-1 subtype B-infected population.
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Development of a cross-European virtual sample repository and HIV resistance database.

Authors: Fanti I, Incardona F, Kjaer J, Kristensen DK, Rickenbach M, Beheydt G, Imbrechts S, Vandamme AM
Journal: Antiviral Therapy
Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=39&SID=2CbhBUDoSw8ZkFBEQLW&page=1&doc=1

Authors: Camacho R, Clotet B, De Luca A, Geretti AM, Grossman Z, Kaiser R, Prosperi M, Schmit JC, Sönnerborg A, Torti C, Van Wijngaerden E, Vercauteren J, Zazzi M, Beheydt G, Imbrechts S, Libin P, Vandamme AM, Van Laethem K
Journal: PLoS One
Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061436

Clinically evaluating genotypic interpretation systems is essential to provide optimal guidance in designing potent individualized HIV-regimens. This study aimed at investigating the ability of the latest Rega algorithm to predict virological response on a short and longer period.
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Structural modifications induced by specific HIV-1 protease-compensatory mutations have an impact on the virological response to a first-line lopinavir/ritonavir-containing regimen

Development of a cross-European virtual sample repository and HIV resistance database.

Clinical Evaluation of Rega 8: An Updated Genotypic Interpretation System That Significantly Predicts HIV-Therapy Response

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