Advances in the molecular diagnosis of tuberculosis: From probes to genomes

Authors: Machado D, Couto I, Viveiros M
Publication Year: 2019
Journal: Infection Genetics and Evolution
Link: https://www.ncbi.nlm.nih.gov/pubmed/30508687

Tuberculosis, disease caused by Mycobacterium tuberculosis, is currently the leading cause of death by a single infectious agent worldwide. Early, rapid and accurate identification of M. tuberculosis and the determination of drug susceptibility is essential for the treatment and management of this disease. Tuberculosis diagnosis is mainly based on chest radiography, smear microscopy and bacteriological […]
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Oral transmission of Trypanosoma cruzi, Brazilian Amazon

Authors: Santana RAG, Guerra MGVB, Sousa DR, Couceiro K, Ortiz JV, Oliveira M, Ferreira LS, Souza KR, Tavares IC, Morais RF, Silva GAV, Melo GC, Vergel GM, Albuquerque BC, Arcanjo ARL, Monteiro WM, Ferreira JMBB, Lacerda MVG, Silveira H, Guerra JAO
Publication Year: 2019
Journal: Emerging Infectious Diseases
Link: https://wwwnc.cdc.gov/eid/article/25/1/18-0646_article

In the Brazilian Amazon, the suspected source of infection in an outbreak of acute Chagas disease involving 10 patients was Euterpe oleracea (açaí berry) juice. Patient blood and juice samples contained Trypanosoma cruzi TcIV, indicating oral transmission of the Chagas disease agent. © 2018, Centers for Disease Control and Prevention (CDC). All rights reserved.
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Alternative strategies for mosquito-borne arbovirus control

Authors: Achee NL, Grieco JP, Vatandoost H, Seixas G, Pinto J, Ching-Ng L, Martins AJ, Juntarajumnong W, Corbel V, Gouagna C, David JP, Logan JG, Orsborne J, Marois E, Devine GJ, Vontas J
Publication Year: 2019
Journal: PLoS Negleted Tropical Diseases
Link: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006822

Background Mosquito-borne viruses—such as Zika, chikungunya, dengue fever, and yellow fever, among others—are of global importance. Although vaccine development for prevention of mosquito-borne arbovirus infections has been a focus, mitigation strategies continue to rely on vector control. However, vector control has failed to prevent recent epidemics and arrest expanding geographic distribution of key arboviruses, such […]
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Trans-sialidase Protein as a Potential Serological Marker for African Trypanosomiasis

Authors: Teixeira AF, Pereira JG, Pestana-Ascensão S, Silva MS
Publication Year: 2019
Journal: Protein Journal
Link: https://www.ncbi.nlm.nih.gov/pubmed/30604107

Trypanosoma brucei is the etiological agent of African trypanosomiasis responsible for human and animal infections. T. brucei is transmitted by infected tsetse flies. There is no vaccine for the disease and drugs available for treatment are inefficient and high toxicity. In this context, it is a priority to find antigenic targets suitable for the development […]
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Time delay and associated mortality from negative smear to positive Xpert MTB/RIF test among TB/HIV patients: A retrospective study 11 Medical and Health Sciences 1103 Clinical Sciences 11 Medical and Health Sciences 1117 Public Health and Health Services

Authors: Lisboa M, Fronteira I, Colove E, Nhamonga M, Martins MRO
Publication Year: 2019
Journal: BMC Infectious Diseases
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322291/

Background The GeneXpert MTB/RIF Assay (Xpert®) is known to be a feasible, effective and a hopeful tool for rapid tuberculosis (TB) diagnosis and treatment. However, little is known about the time delay caused by initial negative sputum smear microscopy (NSSM), but consecutive positive Xpert TB test (PXTBt) and its association with TB mortality in resource-constrained […]
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Advances in the molecular diagnosis of tuberculosis: From probes to genomes

Oral transmission of Trypanosoma cruzi, Brazilian Amazon

Alternative strategies for mosquito-borne arbovirus control

Trans-sialidase Protein as a Potential Serological Marker for African Trypanosomiasis

Time delay and associated mortality from negative smear to positive Xpert MTB/RIF test among TB/HIV patients: A retrospective study 11 Medical and Health Sciences 1103 Clinical Sciences 11 Medical and Health Sciences 1117 Public Health and Health Services

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