GHTM

Global Health and Tropical Medicine

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Home / Archives for 2014

Impact of a training course on the quality of malaria diagnosis by microscopy in Angola

  • Authors: Bernardino L, Brito M, Fançony C, Fortes F, Mirante C, Moura S, Neves M, Sambo MR
  • Publication Year: 2014
  • Journal: Malaria Journal
  • Link: http://www.malariajournal.com/content/13/1/437

This study was implemented in laboratories from three hospitals in different provinces of Angola: Bengo, Benguela and Luanda. In each laboratory samples were collected before and after the training course (slide with thin and thick blood smears, a dried blood spot and a form).
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Clinical and virological response to antiretroviral drugs among HIV patients on first-line treatment in Dar-es-Salaam, Tanzania

  • Authors: Kasubi M, Ledwaba J, Morris L, Mosha F, Ndugulile F, Ng’ang’a Z, Nsubuga P, Swai A, Vandamme AM, Vercauteren J
  • Publication Year: 2014
  • Journal: The Journal of Infection in Developing Countries
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25022294

In Tanzania, the follow-up on antiretroviral therapy (ART) response is based on clinical outcomes. We investigated virological response and ARV resistance mutations in relation to clinical response in ARV-treated patients.
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Where does fear lead us: antiretroviral treatment adherence in Maputo

  • Authors: Cabral A, Gaspar de Matos M, Moreno M
  • Publication Year: 2014
  • Journal: Health
  • Link: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=43914

This research aims to deepen knowledge on the role of fear on ART adherence of patients who live in Maputo district in Mozambique, including differences on age, gender and schooling level, on their previous knowledge about HIV and ART and on the impact of the discrimination experiences on the ART adherence.
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CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis

  • Authors: Alvarez C, Brassat D, Decanine D, Galvão-Castro B, Gotuzzo E, Khouri R, Kruschewsky R, Liblau R, López G, Menezes SM, Schnitman SV, Talledo M, Vandamme AM, Weyenbergh JV
  • Publication Year: 2014
  • Journal: Journal of Neuroinflammation
  • Link: http://www.jneuroinflammation.com/content/11/1/18

Human T-cell lymphotropic virus (HTLV-1) is the causative agent of the incapacitating, neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Currently, there are no disease-modifying therapies with long-term clinical benefits or validated biomarkers for clinical follow-up in HAM/TSP.
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Horizontal gene transfer from human host to HIV-1 reverse transcriptase confers drug resistance and partly compensates for replication deficits

  • Authors: De Baets G, Dekeersmaeker N, Li G, Megens S, Moutschen M, Rousseau F, Schrooten Y, Schymkowitz J, Vaira D, Van Laethem K, Vandamme AM
  • Publication Year: 2014
  • Journal: Virology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/24889250

We investigated the origin and the effect of insertion D67D-THGERDLGPA within HIV-1 RT from a patient failing antiviral therapy. The insertion developed within the context of pre-existing NRTI and NNRTI mutations (M41L, L210W, T215Y and N348I).
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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Funding

UID/04413/2025 - DOI: 10.54499/UID/04413/2025

UID/PRR/04413/2025 - DOI: 10.54499/UID/PRR/04413/2025

UID/PRR2/04413/2025 - DOI: 10.54499/UID/PRR2/04413/2025

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