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Home / Archives for Gotuzzo E

A Fashi lymphoproliferative phenotype reveals non-apoptotic fas signaling in HTLV-1-associated neuroinflammation

  • Autores: Alvarez C, Brassat D, Decanine D, Dierckx T, Galvão-Castro B, Gotuzzo E, Khouri R, Kruschewsky R, Leal FE, Liblau R, López G, Menezes SM, Nixon DF, Schnitman SV, Silva-Santos G, Talledo M, Van Weyenbergh J, Vandamme AM, Vercauteren J
  • Ano de Publicação: 2017
  • Journal: Frontiers in Immunology
  • Link: https://www.frontiersin.org/articles/10.3389/fimmu.2017.00097/full

Human T-cell lymphotropic virus (HTLV)-1 was the first human retrovirus to be associated to cancer, namely adult T-cell leukemia (ATL), but its pathogenesis remains enigmatic, since only a minority of infected individuals develops either ATL or the neuroinflammatory disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). A functional FAS -670 polymorphism in an interferon (IFN)-regulated STAT1-binding site has been […]
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Family aggregation of human T-lymphotropic virus 1-associated diseases: A systematic review

  • Autores: Alvarez C, Gotuzzo E, Vandamme AM, Verdonck K
  • Ano de Publicação: 2016
  • Journal: Frontiers in Microbiology
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083714/

Human T-lymphotropic virus 1 (HTLV-1) is a retrovirus that produces a persistent infection. Two transmission routes (from mother to child and via sexual intercourse) favor familial clustering of HTLV-1. It is yet unknown why most HTLV-1 carriers remain asymptomatic while about 10% of them develop complications. HTLV-1 associated diseases were originally described as sporadic entities, […]
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Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy.

  • Autores: Alvarez C, de Almeida Kruschewsky R, Decanine D, Galvão-Castro B, Gotuzzo E, Khouri R, López G, Menezes SM, Moens B, Silva-Santos G, Talledo M, Van Weyenbergh J
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Ascorbic+Acid+Has+Superior+Ex+Vivo+Antiproliferative%2C+Cell+Death-Inducing+and+Immunomodulatory+Effects+over+IFN-alpha+in+HTLV-1-Associated+Myelopathy

BACKGROUND:
Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar clinical benefit has been demonstrated for IFN-α and high-dose ascorbic acid (AA) monotherapy in a large open clinical trial.
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Simultaneous RNA quantification of human and retroviral genomes reveals intact interferon signaling in HTLV-1-infected CD4+ T cell lines.

  • Autores: Bittencourt A, Farré L, Galvão-Castro B, Gotuzzo E, Khouri R, López G, Moens B, Pannecouque C, Talledo M, Van Weyenbergh J, Vandamme AM
  • Journal: Virology Journal
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Simultaneous+RNA+quantification+of+human+and+retroviral+genomes+reveals+intact+interferon+signaling+in+HTLV-1-infected+CD4%2B+T+cell+lines.

BACKGROUND:
IFN-α contributes extensively to host immune response upon viral infection through antiviral, pro-apoptotic, antiproliferative and immunomodulatory activities. Although extensively documented in various types of human cancers and viral infections, controversy exists in the exact mechanism of action of IFN-α in human immunodeficiency virus type 1 (HIV-1) and human T-lymphotropic virus type 1 (HTLV-1) retroviral infections.
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Research priorities for neglected infectious diseases in Latin America and the Caribbean region

  • Autores: Arevalo J, Boelaert M, Carrasco HJ, Correa-Oliveira R, Do Rosário V, Garcia L, Gotuzzo E, Gyorkos TW, Herrera S, Kalergis AM, Kouri G, Larraga V, Lutumba P, Macias Garcia MA, Manrique-Saide PC, Modabber F, Nieto A, Olesen OF, Pluschke G, Robello C, Rojas de Arias A, Rumbo M, Santos Preciado JI, Sundar S, Torres J, Torrico F, Van der Stuyft P, Victoir K
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/21049009

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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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