GHTM

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Home / Archives for Farré L

IFN-β induces greater antiproliferative and proapoptotic effects and increased p53 signaling compared with IFN-alpha in PBMCs of Adult T-cell Leukemia/Lymphoma patients

  • Autores: Bittencourt A, Decanine D, Dierckx T, Farré L, Khouri R, Menezes SM, Van Weyenbergh J, Vandamme AM
  • Ano de Publicação: 2017
  • Journal: Blood Cancer Journal
  • Link: https://www.nature.com/articles/bcj2016126

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Simultaneous RNA quantification of human and retroviral genomes reveals intact interferon signaling in HTLV-1-infected CD4+ T cell lines.

  • Autores: Bittencourt A, Farré L, Galvão-Castro B, Gotuzzo E, Khouri R, López G, Moens B, Pannecouque C, Talledo M, Van Weyenbergh J, Vandamme AM
  • Journal: Virology Journal
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Simultaneous+RNA+quantification+of+human+and+retroviral+genomes+reveals+intact+interferon+signaling+in+HTLV-1-infected+CD4%2B+T+cell+lines.

BACKGROUND:
IFN-α contributes extensively to host immune response upon viral infection through antiviral, pro-apoptotic, antiproliferative and immunomodulatory activities. Although extensively documented in various types of human cancers and viral infections, controversy exists in the exact mechanism of action of IFN-α in human immunodeficiency virus type 1 (HIV-1) and human T-lymphotropic virus type 1 (HTLV-1) retroviral infections.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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+351 213 652 600
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