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Home / Archives for Galvão-Castro B

A Fashi lymphoproliferative phenotype reveals non-apoptotic fas signaling in HTLV-1-associated neuroinflammation

  • Autores: Alvarez C, Brassat D, Decanine D, Dierckx T, Galvão-Castro B, Gotuzzo E, Khouri R, Kruschewsky R, Leal FE, Liblau R, López G, Menezes SM, Nixon DF, Schnitman SV, Silva-Santos G, Talledo M, Van Weyenbergh J, Vandamme AM, Vercauteren J
  • Ano de Publicação: 2017
  • Journal: Frontiers in Immunology
  • Link: https://www.frontiersin.org/articles/10.3389/fimmu.2017.00097/full

Human T-cell lymphotropic virus (HTLV)-1 was the first human retrovirus to be associated to cancer, namely adult T-cell leukemia (ATL), but its pathogenesis remains enigmatic, since only a minority of infected individuals develops either ATL or the neuroinflammatory disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). A functional FAS -670 polymorphism in an interferon (IFN)-regulated STAT1-binding site has been […]
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A public HTLV-1 molecular epidemiology database for sequence management and data mining.

  • Autores: Alcantara LC, Araújo TH, de Albuquerque-Junior AE, Edwards D, Galvão-Castro B, Souza-Brito LI, Deforche K, Libin P, Vandamme AM
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=A+Public+HTLV-1+Molecular+Epidemiology+Database+for+Sequence+Management+and+Data+Mining

BACKGROUND:
It is estimated that 15 to 20 million people are infected with the human T-cell lymphotropic virus type 1 (HTLV-1). At present, there are more than 2,000 unique HTLV-1 isolate sequences published. A central database to aggregate sequence information from a range of epidemiological aspects including HTLV-1 infections, pathogenesis, origins, and evolutionary dynamics would be useful to scientists and physicians worldwide.
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Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy.

  • Autores: Alvarez C, de Almeida Kruschewsky R, Decanine D, Galvão-Castro B, Gotuzzo E, Khouri R, López G, Menezes SM, Moens B, Silva-Santos G, Talledo M, Van Weyenbergh J
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Ascorbic+Acid+Has+Superior+Ex+Vivo+Antiproliferative%2C+Cell+Death-Inducing+and+Immunomodulatory+Effects+over+IFN-alpha+in+HTLV-1-Associated+Myelopathy

BACKGROUND:
Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar clinical benefit has been demonstrated for IFN-α and high-dose ascorbic acid (AA) monotherapy in a large open clinical trial.
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Simultaneous RNA quantification of human and retroviral genomes reveals intact interferon signaling in HTLV-1-infected CD4+ T cell lines.

  • Autores: Bittencourt A, Farré L, Galvão-Castro B, Gotuzzo E, Khouri R, López G, Moens B, Pannecouque C, Talledo M, Van Weyenbergh J, Vandamme AM
  • Journal: Virology Journal
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Simultaneous+RNA+quantification+of+human+and+retroviral+genomes+reveals+intact+interferon+signaling+in+HTLV-1-infected+CD4%2B+T+cell+lines.

BACKGROUND:
IFN-α contributes extensively to host immune response upon viral infection through antiviral, pro-apoptotic, antiproliferative and immunomodulatory activities. Although extensively documented in various types of human cancers and viral infections, controversy exists in the exact mechanism of action of IFN-α in human immunodeficiency virus type 1 (HIV-1) and human T-lymphotropic virus type 1 (HTLV-1) retroviral infections.
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CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis

  • Autores: Alvarez C, Brassat D, Decanine D, Galvão-Castro B, Gotuzzo E, Khouri R, Kruschewsky R, Liblau R, López G, Menezes SM, Schnitman SV, Talledo M, Vandamme AM, Weyenbergh JV
  • Ano de Publicação: 2014
  • Journal: Journal of Neuroinflammation
  • Link: http://www.jneuroinflammation.com/content/11/1/18

Human T-cell lymphotropic virus (HTLV-1) is the causative agent of the incapacitating, neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Currently, there are no disease-modifying therapies with long-term clinical benefits or validated biomarkers for clinical follow-up in HAM/TSP.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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