A Fashi lymphoproliferative phenotype reveals non-apoptotic fas signaling in HTLV-1-associated neuroinflammation
- Autores: Alvarez C, Brassat D, Decanine D, Dierckx T, Galvão-Castro B, Gotuzzo E, Khouri R, Kruschewsky R, Leal FE, Liblau R, López G, Menezes SM, Nixon DF, Schnitman SV, Silva-Santos G, Talledo M, Van Weyenbergh J, Vandamme AM, Vercauteren J
- Ano de Publicação: 2017
- Journal: Frontiers in Immunology
- Link: https://www.frontiersin.org/articles/10.3389/fimmu.2017.00097/full
Human T-cell lymphotropic virus (HTLV)-1 was the first human retrovirus to be associated to cancer, namely adult T-cell leukemia (ATL), but its pathogenesis remains enigmatic, since only a minority of infected individuals develops either ATL or the neuroinflammatory disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). A functional FAS -670 polymorphism in an interferon (IFN)-regulated STAT1-binding site has been […]
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