Insights on the Mycobacterium tuberculosis population structure associated with migrants from Portuguese-speaking countries over a three-year period in Greater Lisbon, Portugal: Implications at the public health level.

Autores: Pereira C, Gomes P, Taveira R, Silva C, Maltez F, Macedo R, Costa C, Couvin D, Rastogi N, Viveiros M, Perdigão J, Portugal I
Ano de Publicação: 2019
Journal: Infection Genetics and Evolution
Link: https://www.ncbi.nlm.nih.gov/pubmed/30928606

Tuberculosis among foreign-born patients is a key indicator of country-level epidemiological profiles and, of an increasing concern in Europe given the more intensified migratory waves of refugees. Since Portugal presents a lower immigrant-associated TB incidence rate when compared to other European countries, we sought to characterize the epidemiology and transmission dynamics among the foreign-born population […]
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Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glycans terminated by alpha-2–6 sialic acids

Autores: Loureiro LR, Sousa DP, Ferreira D, Chai W, Lima L, Pereira C, Lopes CB, Correia VG, Silva LM, Li C, Santos LL, Ferreira JA, Barbas A, Palma AS, Novo C, Videira PA
Ano de Publicação: 2018
Journal: Scientific Reports
Link: https://www.nature.com/articles/s41598-018-30421-w

Incomplete O-glycosylation is a feature associated with malignancy resulting in the expression of truncated glycans such as the sialyl-Tn (STn) antigen. Despite all the progress in the development of potential anti-cancer antibodies, their application is frequently hindered by low specificities and cross-reactivity. In this study, a novel anti-STn monoclonal antibody named L2A5 was developed by hybridoma […]
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Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries

Autores: Perdigão J, Silva C, Diniz J, Pereira C, Machado D, Ramos J, Silva H, Abilleira F, Brum C, Reis AJ, Macedo M, Scaini JL, Silva AB, Esteves L, Macedo R, Maltez F, Clemente S, Coelho E, Viegas S, Rabna P, Rodrigues A, Taveira N, Jordao L, Kritski A, Lapa e Silva JR, Mokrousov I, Couvin D, Rastogi N, Couto I, Pain A, McNerney R, Clark TG, von Groll A, Dalla Costa ER, Rossetti ML, Silva PEA, Viveiros M, Portugal I
Ano de Publicação: 2019
Journal: Infection Genetics and Evolution
Link: https://www.sciencedirect.com/science/article/pii/S1567134818301023?via%3Dihub%20

Tuberculosis (TB) remains a major health problem within the Community of Portuguese Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across its member-states and continued human migratory flux between countries, a considerable gap in the knowledge on the Mycobacterium tuberculosis population structure and strain circulation between the countries still exists. To address […]
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Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium tuberculosis

Autores: Coelho TS, Couto I, Machado D, Maschmann RA, Perdigão J, Pereira C, Portugal I, Ramos DF, Rossetti MLR, Silva PA, Viveiros M, von Groll A
Ano de Publicação: 2017
Journal: Frontiers in Microbiology
Link: https://www.frontiersin.org/articles/10.3389/fmicb.2017.00711/full

Numerous studies show efflux as a universal bacterial mechanism contributing to antibiotic resistance and also that the activity of the antibiotics subject to efflux can be enhanced by the combined use of efflux inhibitors. Nevertheless, the contribution of efflux to the overall drug resistance levels of clinical isolates of Mycobacterium tuberculosis is poorly understood and […]
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Environmental distribution of Cryptococcus neoformans and C. Gattii around the Mediterranean basin

Autores: Akcaglar S, Al-Yasiri MH, Alonso B, Bertout S, Boekhout T, Caggiano G, Cerikcioglu N, Cogliati M, Colom MF, Criseo G, D'Amicis R, De Giglio O, Desnos-Ollivier M, Dipineto L, Dromer F, Ellabib MS, Ergin C, Ferreira-Paim K, Hagen F, Ilkit M, Inácio J, Kaya M, Korem M, Kwon-Chung KJ, Lockhart SR, Macci C, Mallié M, Marchese A, Martins Mda L, McCormick-Smith I, Meyer W, Mlinaric-Missoni E, Montagna MT, Nardoni S, Oliveri S, Pasquale V, Pereira C, Polacheck I, Ranque S, Rickerts V, Romeo O, Sampaio AC, Scopa A, Serio F, Susever S, Theelen B, Tintelnot K, Tore O, Tortorano AM, Trovato L, Varma A, Velegraki A, Vencà AC, Vezzulli L, Vieira ML, Zani A
Ano de Publicação: 2016
Journal: FEMS Yeast Research
Link: https://academic.oup.com/femsyr/article/16/4/fow045/2680354

In order to elucidate the distribution of Cryptococcus neoformans and C. gattii in the Mediterranean basin, an extensive environmental survey was carried out during 2012-2015. A total of 302 sites located in 12 countries were sampled, 6436 samples from 3765 trees were collected and 5% of trees were found to be colonized by cryptococcal yeasts. […]
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Insights on the Mycobacterium tuberculosis population structure associated with migrants from Portuguese-speaking countries over a three-year period in Greater Lisbon, Portugal: Implications at the public health level.

Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glycans terminated by alpha-2–6 sialic acids

Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries

Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium tuberculosis

Environmental distribution of Cryptococcus neoformans and C. Gattii around the Mediterranean basin

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