Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium tuberculosis
- Autores: Coelho TS, Couto I, Machado D, Maschmann RA, Perdigão J, Pereira C, Portugal I, Ramos DF, Rossetti MLR, Silva PA, Viveiros M, von Groll A
- Ano de Publicação: 2017
- Journal: Frontiers in Microbiology
- Link: https://www.frontiersin.org/articles/10.3389/fmicb.2017.00711/full
Numerous studies show efflux as a universal bacterial mechanism contributing to antibiotic resistance and also that the activity of the antibiotics subject to efflux can be enhanced by the combined use of efflux inhibitors. Nevertheless, the contribution of efflux to the overall drug resistance levels of clinical isolates of Mycobacterium tuberculosis is poorly understood and […]
Ler mais