GHTM

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Home / Archives for Loureiro LR

Development of a novel target module redirecting UniCAR T cells to Sialyl Tn-expressing tumor cells

  • Autores: Loureiro LR, Feldmann A, Bergmann R, Koristka S, Berndt N, Arndt C, Pietzsch J, Novo C, Videira P, Bachmann M
  • Ano de Publicação: 2018
  • Journal: Blood Cancer Journal
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127150/

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Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glycans terminated by alpha-2–6 sialic acids

  • Autores: Loureiro LR, Sousa DP, Ferreira D, Chai W, Lima L, Pereira C, Lopes CB, Correia VG, Silva LM, Li C, Santos LL, Ferreira JA, Barbas A, Palma AS, Novo C, Videira PA
  • Ano de Publicação: 2018
  • Journal: Scientific Reports
  • Link: https://www.nature.com/articles/s41598-018-30421-w

Incomplete O-glycosylation is a feature associated with malignancy resulting in the expression of truncated glycans such as the sialyl-Tn (STn) antigen. Despite all the progress in the development of potential anti-cancer antibodies, their application is frequently hindered by low specificities and cross-reactivity. In this study, a novel anti-STn monoclonal antibody named L2A5 was developed by hybridoma […]
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Challenges in Antibody Development against Tn and Sialyl-Tn Antigens

  • Autores: Barbas A, Carrascal MA, Delannoy P, Loureiro LR, Novo C, Ramalho JS, Videira PA
  • Ano de Publicação: 2015
  • Journal: Biomolecules
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598775/%20

The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and usually absent in healthy tissues. These antigens have been correlated with cancer progression and poor prognosis, and associated with immunosuppressive microenvironment. Presently they are used in clinical trials as therapeutic vaccination, but with limited success due to their low immunogenicity. Alternatively, anti-Tn […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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1349-008 Lisboa
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+351 213 652 600
+351 213 632 105

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