An Unusual Case of Feline Leishmaniosis With Involvement of the Mammary Glands

Authors: Pereira A, Valente J, Parreira R, Cristóvão JM, Azinheira S, Campino L, Maia C
Publication Year: 2019
Journal: Topics in Companion Animal Medicine
Link: https://www.sciencedirect.com/science/article/pii/S1938973619300935

We report an unusual case of leishmaniosis with the involvement of mammary glands in an old cat with what seems to be a concurrent regressive feline leukemia virus infection. Leishmania donovani complex parasites were identified for the first time in inflammatory breast fluid during a clinical recurrence manifested about 4 years after the first diagnosis of feline […]
Read More

In Silico Chemogenomics Drug Repositioning Strategies for Neglected Tropical Diseases

Authors: Andrade CH, Neves BJ, Melo-Filho CC, Rodrigues J, Silva DC, Braga RC, Cravo P
Publication Year: 2019
Journal: Current Medicinal Chemistry
Link: https://www.ncbi.nlm.nih.gov/pubmed/29521204

Only ~1% of all drug candidates against Neglected Tropical Diseases (NTDs) have reached clinical trials in the last decades, underscoring the need for new, safe and effective treatments. In such context, drug repositioning, which allows finding novel indications for approved drugs whose pharmacokinetic and safety profiles are already known, emerging as a promising strategy for […]
Read More

Elucidating in vitro and in vivo phenotypic behaviour of L. infantum/L. major natural hybrids

Authors: Cortes S, Albuquerque-Wendt A, Maia C, Carvalho M, Lima IA, de Freitas LAR, Dos-Santos WLC, Campino L
Publication Year: 2019
Journal: Parasitology
Link: https://www.ncbi.nlm.nih.gov/pubmed/30486907

The clinical manifestation and course of Leishmania infections depend on factors such as species, virulence and host-immunity. Although trypanosomatids are considered to have clonal propagation, genetic hybridization has produced successful natural hybrid lineages. Hybrids displaying strong selective advantages may have an impact on pathogenesis and the eco-epidemiology of leishmaniasis. Thus, characterization of phenotypic properties of […]
Read More

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to solar ultraviolet radiation and of the effect of occupational exposure to solar ultraviolet radiation on melanoma and non-melanoma skin cancer

Authors: Paulo MS, Adam B, Akagwu C, Akparibo I, Al-Rifai RH, Bazrafshan S, Gobba F, Green AC, Ivanov I, Kezic S, Leppink N, Loney T, Modenese A, Pega F, Peters CE, Prüss-Üstün AM, Tenkate T, Ujita Y, Wittlich M, John SM
Publication Year: 2019
Journal: Environment International
Link: https://www.ncbi.nlm.nih.gov/pubmed/30792021

BACKGROUND: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO joint methodology), with contributions from a large network of experts. In this paper, we present the protocol for two systematic reviews of parameters for estimating […]
Read More

Diabetes-related symptoms, acute complications and management of diabetes mellitus of patients who are receiving palliative care: A protocol for a systematic review

Authors: Bettencourt-Silva R, Aguiar B, Sá-Araújo V, Barreira R, Guedes V, Marques Ribeiro MJ, Carvalho D, Östlundh L, Paulo MS
Publication Year: 2019
Journal: BMJ Open
Link: https://www.ncbi.nlm.nih.gov/pubmed/31203247

Introduction Worldwide, an estimated 40 million people are in need of palliative care each year, but only 14% receive it. The incidence of diabetes mellitus (DM) in patients receiving palliative care is higher than in the general population. This association is intended to grow as a result of the rising burden of DM worldwide, ageing populations and […]
Read More

An Unusual Case of Feline Leishmaniosis With Involvement of the Mammary Glands

In Silico Chemogenomics Drug Repositioning Strategies for Neglected Tropical Diseases

Elucidating in vitro and in vivo phenotypic behaviour of L. infantum/L. major natural hybrids

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to solar ultraviolet radiation and of the effect of occupational exposure to solar ultraviolet radiation on melanoma and non-melanoma skin cancer

Diabetes-related symptoms, acute complications and management of diabetes mellitus of patients who are receiving palliative care: A protocol for a systematic review

About GHTM

Contacts

Funding