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Home / Archives for Plos Neglected Tropical Diseases

Seasonal Dynamics of Phlebotomine Sand Fly Species Proven Vectors of Mediterranean Leishmaniasis Caused by Leishmania infantum

  • Authors: Afonso MO, Alten B, Antoniou M, Arserim SK, Bañuls AL, Bianchi R, Bongiorno G, Campino L, Cassan C, Christodoulou V, Dokianakis E, Erisoz Kasap O, Giorgobiani E, González E3, Gradoni L, Gramiccia M, Gunay F, Jimenez M, Karakus M, Kaynas S, Khoury C, Maia C, Mazeris A, Molina R, Oguz G, Ozbel Y, Prudhomme J, Rahola N, Sereno D, Thierry M, Toty C, Tsertsvadze N, Tsirigotakis N, Tskhvaradze L, Vergnes B, Volf P
  • Publication Year: 2016
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004458

The recent geographical expansion of phlebotomine vectors of Leishmania infantum in the Mediterranean subregion has been attributed to ongoing climate changes. At these latitudes, the activity of sand flies is typically seasonal; because seasonal phenomena are also sensitive to general variations in climate, current phenological data sets can provide a baseline for continuing investigations on […]
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Zika Virus, a New Threat for Europe?

  • Authors: Failloux AB, Jupille H, Mousson L, Seixas G, Sousa CA
  • Publication Year: 2016
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004901

BACKGROUND: Since its emergence in 2007 in Micronesia and Polynesia, the arthropod-borne flavivirus Zika virus (ZIKV) has spread in the Americas and the Caribbean, following first detection in Brazil in May 2015. The risk of ZIKV emergence in Europe increases as imported cases are repeatedly reported. Together with chikungunya virus (CHIKV) and dengue virus (DENV), […]
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Tracking Insecticide Resistance in Mosquito Vectors of Arboviruses: The Worldwide Insecticide resistance Network (WIN)

  • Authors: Achee NL, Chandre F, Ching Ng L, Corbel V, Coulibaly MB, David JP, Dusfour I, Fonseca DM, Fouque F, Grieco J, Juntarajumnong W, Lenhart A, Martins A, Moyes C, Pinto J, Raghavendra K, Vatandoost H, Velayudhan R, Vontas J, Weetman D
  • Publication Year: 2016
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005054

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Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy.

  • Authors: Alvarez C, de Almeida Kruschewsky R, Decanine D, Galvão-Castro B, Gotuzzo E, Khouri R, López G, Menezes SM, Moens B, Silva-Santos G, Talledo M, Van Weyenbergh J
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Ascorbic+Acid+Has+Superior+Ex+Vivo+Antiproliferative%2C+Cell+Death-Inducing+and+Immunomodulatory+Effects+over+IFN-alpha+in+HTLV-1-Associated+Myelopathy

BACKGROUND:
Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar clinical benefit has been demonstrated for IFN-α and high-dose ascorbic acid (AA) monotherapy in a large open clinical trial.
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Trypanosoma cruzi I and IV Stocks from Brazilian Amazon Are Divergent in Terms of Biological and Medical Properties in Mice

  • Authors: Bahia MT, de Araújo SM, de Oliveira Guerra JA, dos Reis D, Gomes ML, Gruendling AP, Magalhaes LK, Margioto Teston AP, Monteiro WM, Silveira H, Toledo MJ, Vale Barbosa Md
  • Publication Year: 2013
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002069

In the Brazilian Amazon, clinical and epidemiological frameworks of Chagas disease are very dissimilar in relation to the endemic classical areas of transmission, possibly due to genetic and biological characteristics of the circulating Trypanosoma cruzi stocks. Twenty six T. cruzi stocks from Western Amazon Region attributed to the TcI and TcIV DTUs were comparatively studied in Swiss mice to test the hypothesis that T. cruzi clonal structure has a major impact on its biological and medical properties.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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