Thermal and magnetic properties of chitosan-iron oxide nanoparticles

Authors: Borges P, Coutinho JT, Ferreira IMM, Laia C, Machado D, Novo C, Pereira LCJ, Soares PIP
Publication Year: 2016
Journal: Carbohydrate Polymers
Link: https://www.sciencedirect.com/science/article/pii/S0144861716305008

Chitosan is a biopolymer widely used for biomedical applications such as drug delivery systems, wound healing, and tissue engineering. Chitosan can be used as coating for other types of materials such as iron oxide nanoparticles, improving its biocompatibility while extending its range of applications. In this work iron oxide nanoparticles (Fe3O4 NPs) produced by chemical […]
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Beyond extensively drug-resistant tuberculosis in Lisbon, Portugal: a case of linezolid resistance acquisition presenting as an iliopsoas abscess

Authors: Couto I, Machado D, Maltez F, Perdigão J, Pereira C, Portugal I, Silva C, Silva H, Viveiros M
Publication Year: 2016
Journal: International Journal of Antimicrobial Agents
Link: https://www.sciencedirect.com/science/article/pii/S0924857916302692?via%3Dihub

Authors: Azzali E, Coelho T, Costa SS, Couto I, da Silva PEA, Lopes E, Machado D, Pieroni M, Viveiros M
Publication Year: 2016
Journal: ASSAY and Drug Development Technologies
Link: https://www.liebertpub.com/doi/pdf/10.1089/adt.2016.752

Infections caused by Mycobacterium tuberculosis and other mycobacteria are major challenges for global public health. Particularly worrisome are infections caused by multidrug-resistant bacteria, which are increasingly difficult to treat because of the loss of efficacy of the current antibacterial agents, a problem that continues to escalate worldwide. There has been a limited interest and investment […]
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The variability and reproducibility of whole genome sequencing technology for detecting resistance to anti-tuberculous drugs

Authors: Campino S, Clark TG, Dheda K, Huggett JF, Machado D, McNerney R, O'Grady J, O'Sullivan DM, Phelan J, Ramos J, Viveiros M, Whale AS
Publication Year: 2016
Journal: Genome Medicine
Link: https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-016-0385-x

The emergence of resistance to anti-tuberculosis drugs is a serious and growing threat to public health. Next-generation sequencing is rapidly gaining traction as a diagnostic tool for investigating drug resistance in Mycobacterium tuberculosis to aid treatment decisions. However, there are few little data regarding the precision of such sequencing for assigning resistance profiles.
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Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis.

Authors: Amaral L, Baptista P, Couto I, Machado D, Perdigão J, Portugal I, Rodrigues L, Veigas B, Viveiros M
Journal: PLoS One
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Contribution+of+Efflux+to+the+Emergence+of+Isoniazid+and+Multidrug+Resistance+in+Mycobacterium+tuberculosis

Multidrug resistant (MDR) tuberculosis is caused by Mycobacterium tuberculosis resistant to isoniazid and rifampicin, the two most effective drugs used in tuberculosis therapy. Here, we investigated the mechanism by which resistance towards isoniazid develops and how overexpression of efflux pumps favors accumulation of mutations in isoniazid targets, thus establishing a MDR phenotype.
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Thermal and magnetic properties of chitosan-iron oxide nanoparticles

Beyond extensively drug-resistant tuberculosis in Lisbon, Portugal: a case of linezolid resistance acquisition presenting as an iliopsoas abscess

An Experimental Model for the Rapid Screening of Compounds with Potential Use Against Mycobacteria

The variability and reproducibility of whole genome sequencing technology for detecting resistance to anti-tuberculous drugs

Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis.

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