The variability and reproducibility of whole genome sequencing technology for detecting resistance to anti-tuberculous drugs
- Autores: Campino S, Clark TG, Dheda K, Huggett JF, Machado D, McNerney R, O'Grady J, O'Sullivan DM, Phelan J, Ramos J, Viveiros M, Whale AS
- Ano de Publicação: 2016
- Journal: Genome Medicine
- Link: https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-016-0385-x
The emergence of resistance to anti-tuberculosis drugs is a serious and growing threat to public health. Next-generation sequencing is rapidly gaining traction as a diagnostic tool for investigating drug resistance in Mycobacterium tuberculosis to aid treatment decisions. However, there are few little data regarding the precision of such sequencing for assigning resistance profiles.