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Home / Archives for International Journal of Antimicrobial Agents

Genomic-based surveillance reveals high ongoing transmission of multi-drug-resistant Mycobacterium tuberculosis in Southern Brazil

  • Autores: Richard Steiner Salvato, Ana Júlia Reis, Sun Hee Schiefelbein, Michael Andrés Abril Gómez, Stéphanie Steiner Salvato, Larissa Vitória da Silva, Elis Regina Dalla Costa, Gisela Unis, Claudia Fontoura Dias, Miguel Viveiros, Isabel Portugal, Andrea von Groll, Pedro Eduardo Almeida da Silva, Afrânio Lineu Kritski, João Perdigão, Maria Lucia Rosa Rossetti
  • Ano de Publicação: 2021
  • Journal: International Journal of Antimicrobial Agents, 58(4), art 106401
  • Link: https://doi.org/10.1016/j.ijantimicag.2021.106401

HIGHLIGHTS • Disputed mutations were found in 21.9% of strains resistant to isoniazid alone, evidencing underestimation of multi-drug resistance. • 73.4% of multi-drug-resistant cases were linked to ongoing transmission events. • Intracluster acquisition of novel drug-resistance mutations was found, revealing important amplification of resistance. ABSTRACT Genomic-based surveillance on the occurrence of drug resistance and its […]
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In vitro and in silico analysis of the efficiency of tetrahydropyridines as drug efflux inhibitors in Escherichia coli

  • Autores: Almeida da Silva PE, Bonacorso HG, Cantos J, Carrion LL, Costa SS, Couto I, Fernandes LD, Junqueira E, Machado KS, Martins MA, Ramos DF, Seus VR, Silva L Jr, Viveiros M, von Groll A, Zanatta N
  • Ano de Publicação: 2017
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ijaaonline.com/article/S0924-8579(17)30026-2/fulltext

The objectives of this study were to evaluate tetrahydropyridine derivatives as efflux inhibitors and to understand the mechanism of action of the compounds by in silico studies. Minimum inhibitory concentration (MIC) determination, fluorometric methods and docking simulations were performed. The compounds NUNL02, NUNL09 and NUNL10 inhibited efflux, and NUNL02 is very likely a substrate of […]
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Beyond extensively drug-resistant tuberculosis in Lisbon, Portugal: a case of linezolid resistance acquisition presenting as an iliopsoas abscess

  • Autores: Couto I, Machado D, Maltez F, Perdigão J, Pereira C, Portugal I, Silva C, Silva H, Viveiros M
  • Ano de Publicação: 2016
  • Journal: International Journal of Antimicrobial Agents
  • Link: https://www.sciencedirect.com/science/article/pii/S0924857916302692?via%3Dihub

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Antibacterial properties of compounds isolated from Carpobrotus edulis.

  • Autores: Amaral L, Hohmann J, Martins A, Molnar J, Vasas A, Viveiros M
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/21411294

Several compounds isolated from the plant Carpobrotus edulis were evaluated for their activity against multidrug-resistant (MDR) bacteria and their efflux pump systems.
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Role of calcium in the efflux system of Escherichia coli.

  • Autores: Amaral L, Cerca P, Costa S, Machado L, Martins A, Spengler G, Viveiros M
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Role+of+calcium+in+the+efflux+system+of+Escherichia+coli.

Efflux of antibiotics by Escherichia coli AG100 is performed by a variety of efflux pumps, ensuring survival of the bacterium in widely diverse media. At pH 5, efflux is independent of metabolic energy during the period of time the assay is conducted; at pH 8 it is totally dependent upon metabolic energy.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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