GHTM

Global Health and Tropical Medicine

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Genomic-based surveillance reveals high ongoing transmission of multi-drug-resistant Mycobacterium tuberculosis in Southern Brazil

HIGHLIGHTS • Disputed mutations were found in 21.9% of strains resistant to isoniazid alone, evidencing underestimation of multi-drug resistance. • 73.4% of multi-drug-resistant cases were linked to ongoing transmission events. • Intracluster acquisition of novel drug-resistance mutations was found, revealing important amplification of resistance. ABSTRACT Genomic-based surveillance on the occurrence of drug resistance and its […]
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In vitro and in silico analysis of the efficiency of tetrahydropyridines as drug efflux inhibitors in Escherichia coli

The objectives of this study were to evaluate tetrahydropyridine derivatives as efflux inhibitors and to understand the mechanism of action of the compounds by in silico studies. Minimum inhibitory concentration (MIC) determination, fluorometric methods and docking simulations were performed. The compounds NUNL02, NUNL09 and NUNL10 inhibited efflux, and NUNL02 is very likely a substrate of […]
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Role of calcium in the efflux system of Escherichia coli.

Efflux of antibiotics by Escherichia coli AG100 is performed by a variety of efflux pumps, ensuring survival of the bacterium in widely diverse media. At pH 5, efflux is independent of metabolic energy during the period of time the assay is conducted; at pH 8 it is totally dependent upon metabolic energy.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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1349-008 Lisboa
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+351 213 652 600
+351 213 632 105

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