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Home / Archives for Almeida da Silva PE

Tetrahydropyridine derivative as efflux inhibitor in Mycobacterium abscessus

  • Autores: Vianna JS, Ramis IB, Bierhals D, von Groll A, Ramos DF, Zanatta N, Lourenço MC, Viveiros M, Almeida da Silva PE
  • Ano de Publicação: 2019
  • Journal: Journal of General Virology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30630106

OBJECTIVES: This study aimed to evaluate a tetrahydropyridine derivative (THP) as a potential inhibitor of the efflux mechanism and modulator of the high level of antimicrobial resistance usually observed in members of the Mycobacterium abscessus (M. abscessus) group. METHODS: The strain M. abscessus subsp. abscessus (ATCC 19997) was used as reference, in addition to three […]
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Efflux Pumps in Mycobacteria: Antimicrobial Resistance, Physiological Functions, and Role in Pathogenicity

  • Autores: Almeida da Silva PE, Couto I, Machado D, Ramos D, Viveiros M, von Groll A
  • Ano de Publicação: 2016
  • Journal: Efflux-Mediated Antimicrobial Resistance in Bacteria
  • Link: https://link.springer.com/chapter/10.1007/978-3-319-39658-3_21%20

The emergence of multidrug and extensively drug-resistant tuberculosis represents a major threat to the control of the disease. Antimicrobial drug resistance in Mycobacterium tuberculosis is not merely a consequence of the occurrence of gene mutations in the drug targets but a balance between the acquisition of mutations and drug efflux. The low permeability of the […]
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In vitro and in silico analysis of the efficiency of tetrahydropyridines as drug efflux inhibitors in Escherichia coli

  • Autores: Almeida da Silva PE, Bonacorso HG, Cantos J, Carrion LL, Costa SS, Couto I, Fernandes LD, Junqueira E, Machado KS, Martins MA, Ramos DF, Seus VR, Silva L Jr, Viveiros M, von Groll A, Zanatta N
  • Ano de Publicação: 2017
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ijaaonline.com/article/S0924-8579(17)30026-2/fulltext

The objectives of this study were to evaluate tetrahydropyridine derivatives as efflux inhibitors and to understand the mechanism of action of the compounds by in silico studies. Minimum inhibitory concentration (MIC) determination, fluorometric methods and docking simulations were performed. The compounds NUNL02, NUNL09 and NUNL10 inhibited efflux, and NUNL02 is very likely a substrate of […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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