- Autores: Amaral L, Hohmann J, Martins A, Molnar J, Vasas A, Viveiros M
- Journal: International Journal of Antimicrobial Agents
- Link: http://www.ncbi.nlm.nih.gov/pubmed/21411294
Several compounds isolated from the plant Carpobrotus edulis were evaluated for their activity against multidrug-resistant (MDR) bacteria and their efflux pump systems. Amongst the compounds isolated, six compounds were tested, namely uvaol, β-amyrin, oleanolic acid, catechin, epicatechin and monogalactosyldiacylglycerol. Oleanolic acid presented high antibacterial activity against a large number of bacterial strains. The triterpene uvaol was the most active compound for modulation of efflux activity by MDR Gram-positive strains.