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Home / Archives for International Journal of Antimicrobial Agents

Inhibition of efflux pumps in methicillin-resistant Staphylococcus aureus and Enterococcus faecalis resistant strains by triterpenoids from Momordica balsamina.

  • Autores: Amaral L, Ferreira MJ, Martins A, Martins M, Mulhovo S, Ramalhete C, Spengler G, Viveiros M
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Inhibition+of+efflux+pumps+in+methicillin-resistant+Staphylococcus+aureus+and+Enterococcus+faecalis+resistant+strains+by+triterpenoids+from+Momordica+balsamina.

Six cucurbitane-type triterpenoids (1-6) isolated from the aerial parts of Momordica balsamina were evaluated for their ability to inhibit the activity of bacterial efflux pumps of methicillin-resistant Staphylococcus aureus (MRSA) COL(OXA), Enterococcus faecalis ATCC 29212, Salmonella enterica subsp.
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Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74

  • Autores: Amaral L, Chaki S, Christensen JB, Dasgupta A, Dastidar SG, Hendricks O, Kristiansen JE, Mukherjee S
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Thioridazine+protects+the+mouse+from+a+virulent+infection+by+Salmonella+enterica+serovar+Typhimurium+74

When administered to mice at doses of 100microg/mouse and 200microg/mouse, thioridazine (TDZ) significantly protected animals from the lethality produced by a virulent strain of Salmonella enterica serovar Typhimurium and reduced the number of bacteria retrieved from the spleen, liver and heart blood.
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Ethidium bromide efflux by Salmonella: modulation by metabolic energy, pH, ions and phenothiazines

  • Autores: Amaral L, Cerca P, Couto I, Fanning S, Machado L, Martins A, Pagès JM, Spengler G, Viveiros M
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Ethidium+bromide+efflux+by+Salmonella%3A+modulation+by+metabolic+energy%2C+pH%2C+ions+and+phenothiazines

The main efflux pump of Salmonella enterica serotype Enteritidis, which obtains its energy for the extrusion of noxious agents from the proton-motive force, was studied with the aid of an ethidium bromide (EtBr) semi-automated method under conditions that define the role of metabolic energy, ions and pH in the extrusion of the universal substrate EtBr.
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Identification of the plasmid-encoded qacA efflux pump gene in meticillin-resistant Staphylococcus aureus (MRSA) strain HPV107, a representative of the MRSA Iberian clone

  • Autores: Amaral L, Costa SS, Couto I, Martins A, Ntokou E, Pournaras S, Viveiros M
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Identification+of+the+plasmid+encoded+qacA+efflux+pump+gene+in+the+methicillin-resistant+Staphylococcus+aureus+(MRSA)+strain+HPV107%2C+a+representative+of+the+MRSA+Iberian+clone

Meticillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial bacterium for which prevention and control measures consist mainly of the application of biocides with antiseptic and disinfectant activity.
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Quinazoline derivatives are efficient chemosensitizers of antibiotic activity in Enterobacter aerogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa resistant strains

  • Autores: Adam E, Amaral L, Baitiche M, Chevalier J, Mahamoud A, Militaru A, Pagès JM, Pascu ML, Smarandache A, Viveiros M
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Quinazoline+derivatives+are+efficient+chemosensitizers+of+antibiotic+activity+in+Enterobacter+aerogenes%2C+Klebsiella+pneumoniae+and+Pseudomonas+aeruginosa+resistant+strains

Amongst the three series of quinazoline derivatives synthesised and studied in this work, some molecules increase the antibiotic susceptibility of Gram-negative bacteria presenting multidrug-resistant phenotypes.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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