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Home / Archives for 2018

Ethical considerations in global HIV phylogenetic research

  • Authors: Amon JJ, Cohen MS, Coltart CEM, Dallabetta G, Dawson L, Eba P, Ethics in HIV Phylogenetics Working Group, Fraser C, Geller G, Godfrey-Faussett P, Grabowski MK, Harling G, Henderson G, Hoppe A, Laeyendecker O, Novitsky V, Parker M, Pillay D, Seeley J, Simwinga M, Tucker JD, Vandamme AM
  • Publication Year: 2018
  • Journal: The Lancet HIV
  • Link: https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(18)30134-6/fulltext

Phylogenetic analysis of pathogens is an increasingly powerful way to reduce the spread of epidemics, including HIV. As a result, phylogenetic approaches are becoming embedded in public health and research programmes, as well as outbreak responses, presenting unique ethical, legal, and social issues that are not adequately addressed by existing bioethics literature. We formed a […]
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Laboratory methods in molecular epidemiology: Viral infections

  • Authors: Parreira R
  • Publication Year: 2018
  • Journal: Microbiology Spectrum
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30387412

Viruses, which are the most abundant biological entities on the planet, have been regarded as the “dark matter” of biology in the sense that despite their ubiquity and frequent presence in large numbers, their detection and analysis are not always straightforward. The majority of them are very small (falling under the limit of 0.5 μm), […]
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Multiple Class i and Class II Haemophilus ducreyi Strains Cause Cutaneous Ulcers in Children on an Endemic Island

  • Authors: Abecasis A, Amick KM, Fortney KR, Gangaiah D, González-Beiras C, Grant JC, Humphreys TL, Mitjà O, Spinola SM
  • Publication Year: 2018
  • Journal: Clinical Infectious Diseases
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29897409

BACKGROUND: Together with Treponema pallidum subspecies pertenue, Haemophilus ducreyi is a major cause of exudative cutaneous ulcers (CUs) in children. For H. ducreyi, both class I and class II strains, asymptomatic colonization, and environmental reservoirs have been found in endemic regions, but the epidemiology of this infection is unknown. METHODS: Based on published whole-genome sequences […]
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Country activities of Global Alliance against Chronic Respiratory Diseases (GARD): focus presentations at the 11th GARD General Meeting, Brussels

  • Authors: Al-Zahab BA, AlJaber A, Aloush J, Alzein A, Arrais M, Bárbara C, Bedbrook A, Bousquet J, Calderon MA, Camargos P, Conceição C, Cossa A, Cruz AA, Dib G, Dmeirieh A, Do Céu Teixeira M, Ekinci B, Faroun H, Fatmeh Y, Ferrinho P, Gemicioglu B, George F, German Z, Gómez RM, González-Díaz SN, Halloum R, Hurd S, Kiley JP, Kolek V, Lan LTT, Lenfant C, McGihon R, Melo-Gomes E, Mohammad Y, Nunes E, Ozkan Z, Punturieri A, Rosado-Pinto J, Rostan MV, Shaaban R, Shifa R, Simão P, Špicák V, Stelmach R, To T, Urrutia-Pereira M, Yañez A, Yorgancioglu A
  • Publication Year: 2018
  • Journal: Journal of Thoracic Disase
  • Link: http://jtd.amegroups.com/article/view/26227/html

The Global Alliance against Chronic Respiratory Diseases (GARD) is a voluntary network of national and international organizations, institutions and agencies led by the World Health Organization (WHO), working towards the vision of a world where all people breathe freely (1). GARD is supporting WHO in successfully implementing the WHO’s Global Action Plan for the Prevention […]
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Insights on Mycobacterium leprae Efflux Pumps and Their Implications in Drug Resistance and Virulence

  • Authors: Cambau E, lecorche E, Machado D, Mougari F, Viveiros M
  • Publication Year: 2018
  • Journal: Frontiers in Microbiology
  • Link: https://www.frontiersin.org/articles/10.3389/fmicb.2018.03072/full

Drug resistance in Mycobacterium leprae is assumed to be due to genetic alterations in the drug targets and reduced cell wall permeability. However, as observed in Mycobacterium tuberculosis, drug resistance may also result from the overactivity of efflux systems, which is mostly unexplored. In this perspective, we discuss known efflux pumps involved in M. tuberculosis drug resistance and virulence and […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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UID/04413/2025 - DOI: 10.54499/UID/04413/2025

UID/PRR/04413/2025 - DOI: 10.54499/UID/PRR/04413/2025

UID/PRR2/04413/2025 - DOI: 10.54499/UID/PRR2/04413/2025

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