GHTM

Global Health and Tropical Medicine

Home / Archives for 2017

Outbreak of human malaria caused by Plasmodium simium in the Atlantic Forest in Rio de Janeiro: A molecular epidemiological investigation

Background Malaria was eliminated from southern and southeastern Brazil over 50 years ago. However, an increasing number of autochthonous episodes attributed to Plasmodium vivax have recently been reported from the Atlantic Forest region of Rio de Janeiro state. As the P vivax-like non-human primate malaria parasite species Plasmodium simium is locally enzootic, we performed a molecular epidemiological investigation to determine […]
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Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli

Efflux pump inhibitors are of great interest since their use as adjuvants of bacterial chemotherapy can increase the intracellular concentrations of the antibiotics and assist in the battle against the rising of antibiotic-resistant bacteria. In this work, we have described the mode of action of the 2-phenylquinoline efflux inhibitor (4-(2-(piperazin-1-yl)ethoxy)-2-(4-propoxyphenyl) quinolone – PQQ4R), against Escherichia coli, by studding […]
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Healthy respiratory microbiome: an innovative project within the first birth cohort in Angola

Childhood pneumonia remains the major infant killer worldwide and displays a particularly devastating effect in sub-Saharan Africa despite the implementation and scaling-up of preventive programs and early management against paediatric pneumonia in developing countries. Studying the human microbiome and its positive effects in health may be one of the answers needed to tackle paediatric mortality […]
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MedTROP – Open Access directory of Tropical Medicine and International Public Health for a Sustainable Development: base for a proposal 

MedTROP project is a partnership between Institute of Hygiene and Tropical Medicine in Portugal and the National School of Public Health / Fundação Oswaldo Cruz, Rio de Janeiro – Brasil. The project aims to make science accessible to citizens. It also aims to reuse, in the future, scientific data in the field of tropical medicine and […]
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In vitro and in silico analysis of the efficiency of tetrahydropyridines as drug efflux inhibitors in Escherichia coli

The objectives of this study were to evaluate tetrahydropyridine derivatives as efflux inhibitors and to understand the mechanism of action of the compounds by in silico studies. Minimum inhibitory concentration (MIC) determination, fluorometric methods and docking simulations were performed. The compounds NUNL02, NUNL09 and NUNL10 inhibited efflux, and NUNL02 is very likely a substrate of […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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Funding

UID/04413/2025 - DOI: 10.54499/UID/04413/2025

UID/PRR/04413/2025 - DOI: 10.54499/UID/PRR/04413/2025

UID/PRR2/04413/2025 - DOI: 10.54499/UID/PRR2/04413/2025