Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli

• Autores: Cannalire R, Costa SS, Couto I, Fernandes L, Machado D, Manfroni G, Sabatini S, Tabarrini O, Viveiros M
• Ano de Publicação: 2017
• Journal: PeerJ
• Link: https://peerj.com/articles/3168/%20

Efflux pump inhibitors are of great interest since their use as adjuvants of bacterial chemotherapy can increase the intracellular concentrations of the antibiotics and assist in the battle against the rising of antibiotic-resistant bacteria. In this work, we have described the mode of action of the 2-phenylquinoline efflux inhibitor (4-(2-(piperazin-1-yl)ethoxy)-2-(4-propoxyphenyl) quinolone – PQQ4R), against Escherichia coli, by studding […]
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