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Global Health and Tropical Medicine

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Home / Archives for Pinto J

Genetic isolation within the malaria mosquito Anopheles melas.

  • Authors: Athrey G, Caccone A, Costantini C, Deitz KC, Della Torre A, Jawara M, Kengne P, Kiszewski AE, Matias A, Overgaard HJ, Petrarca V, Pinto J, Reddy MR, Slotman MA
  • Journal: Molecular Ecology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/22882458

Anopheles melas is a brackish water-breeding member of the Anopheles gambiae complex that is distributed along the coast of West Africa and is a major malaria vector within its range. Because little is known about the population structure of this species, we analysed 15 microsatellite markers and 1161 bp of mtDNA in 11 A.
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Gene flow-dependent genomic divergence between Anopheles gambiae M and S forms.

  • Authors: Donnelly MJ, Steen K, Weetman D, Wilding CS, Pinto J
  • Journal: Molecular Biology and Evolution
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Gene+Flow-Dependent+Genomic+Divergence+between+Anopheles+gambiae+M+and+S+Forms.

Anopheles gambiae sensu stricto exists as two often-sympatric races termed the M and S molecular forms, characterized by fixed differences at an X-linked marker. Extreme divergence between M and S forms at pericentromeric “genomic islands” suggested that selection on variants therein could be driving interform divergence in the presence of ongoing gene flow, but recent work has detected much more widespread genomic differentiation.
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The Culex pipiens complex in continental Portugal: distribution and genetic structure.

  • Authors: Almeida AP, Donnelly MJ, Gomes B, Novo MT, Parreira R, Sousa CA, Pinto J
  • Journal: Journal of the American Mosquito Control Association
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=The+Culex+pipiens+complex+in+continental+Portugal%3A+Distribution+and+genetic+structure.

Portugal is a southern European country that displays favorable ecological conditions for the establishment of West Nile virus (WNV) transmission cycles. Competent mosquito vector species are present throughout the country.
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Geographic structuring of the Plasmodium falciparum sarco(endo)plasmic reticulum Ca2+ ATPase (PfSERCA) gene diversity

  • Authors: Alecrim Md, Benito A, Berzosa P, Bouchier C, Cravo P, Ekala MT, Fandeur T, Ferreira C, Ferreira ID, Gribaldo S, Jambou R, Kim N, Legrand E, Martinelli A, Mercereau-Puijalon O, Niang M, Pharath L, Pinto J, Vieira PP, Volnay B
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Geographic+structuring+of+the+Plasmodium+falciparum+Sarco(endo)plasmic+reticulum+Ca2%2B+ATPase+(PfSERCA)+gene+diversity

Artemisinin, a thapsigargin-like sesquiterpene has been shown to inhibit the Plasmodium falciparum sarco/endoplasmic reticulum calcium-ATPase PfSERCA. To collect baseline pfserca sequence information before field deployment of Artemisinin-based Combination therapies that may select mutant parasites, we conducted a sequence analysis of 100 isolates from multiple sites in Africa, Asia and South America. Coding sequence diversity was […]
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Studies on the behaviour of peridomestic and endophagic M form Anopheles gambiae from a rice growing area of Ghana.

  • Authors: Charlwood JD, Egyir-Yawson A, Pitts RJ, Salgueiro P, Tomás EV, Pinto J
  • Journal: Bulletin of Entomological Research
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Studies+on+the+behaviour+of+peridomestic+and+endophagic+M+form+Anopheles+gambiae+from+a+rice+growing+area+of+Ghana

The ‘paddy paradox’, the occurrence of large populations of vectors but low amounts of malaria transmission where irrigated rice is grown, was investigated in a village in Ghana where M form Anopheles gambiae are common.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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Funding

UID/04413/2025 - DOI: 10.54499/UID/04413/2025

UID/PRR/04413/2025 - DOI: 10.54499/UID/PRR/04413/2025

UID/PRR2/04413/2025 - DOI: 10.54499/UID/PRR2/04413/2025

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    UIDP/04413/2020

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