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Home / Archives for Pinto J

Aedes aegypti on Madeira Island (Portugal): genetic variation of a recently introduced dengue vector. Memórias do Instituto Oswaldo Cruz

  • Authors: Campos M, Novo MT, Pinto J, Reyes-Lugo M, Ribolla PEM, Salgueiro P, Seixas G, Silva AC, Sousa CA, Spenassatto C
  • Journal: Memórias do Instituto Oswaldo Cruz
  • Link: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000900003

The increasing population of Aedes aegypti mosquitoes on Madeira Island (Portugal) resulted in the first autochthonous dengue outbreak, which occurred in October 2012. Our study establishes the first genetic evaluation based on the mitochondrial DNA (mtDNA) genes [cytochrome oxidase subunit I (COI) and NADH dehydrogenase subunit 4 (ND4)] and knockdown resistance ( kdr ) mutations exploring the colonisation history and the genetic diversity of this insular vector population.
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New Insights into the Population Structure of Anopheles gambiae s.s. in the Gulf of Guinea Islands Revealed by Herves Transposable Elements

  • Authors: Moreno M, O’Brochta D, Salgueiro P, Simard F, Pinto J
  • Journal: PLoS One
  • Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062964

Transposable elements (TEs) are mobile portions of DNA that are able to replicate and spread in the genome of many organisms. TEs can be used as a means to insert transgenes in insects, being stably inherited throughout generations.
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The “far-west” of Anopheles gambiae molecular forms.

  • Authors: Besansky NJ, Caputo B, Conway DJ, Della Torre A, Jaenson T, Jawara M, Mancini E, Nwakanma DC, Palsson K, Petrarca V, Santolamazza F, Vicente JL, White BJ
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=The+%E2%80%9Cfar-west%E2%80%9D+of+Anopheles+gambiae+molecular+forms

The main Afrotropical malaria vector, Anopheles gambiae sensu stricto, is undergoing a process of sympatric ecological diversification leading to at least two incipient species (the M and S molecular forms) showing heterogeneous levels of divergence across the genome.
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Field, genetic, and modeling approaches show strong positive selection acting upon an insecticide resistance mutation in Anopheles gambiae s.s

  • Authors: Barbosa S, Donnelly MJ, Egyir-Yawson A, Hastings I, Lynd A, Mitchell S, Weetman D, Pinto J
  • Journal: Molecular Biology and Evolution
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Field%2C+genetic+and+modeling+approaches+show+strong+positive+selection+acting+upon+an+insecticide+resistance+mutation+in+Anopheles+gambiae+s.s

Alleles subject to strong, recent positive selection will be swept toward fixation together with contiguous sections of the genome. Whether the genomic signatures of such selection will be readily detectable in outbred wild populations is unclear. In this study, we employ haplotype diversity analysis to examine evidence for selective sweeps around knockdown resistance (kdr) mutations […]
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Geographic population structure of the African malaria vector Anopheles gambiae suggests a role for the forest-savannah biome transition as a barrier to gene flow

  • Authors: Caccone A, Charlwood JD, Della Torre A, Donnelly MJ, Egyir-Yawson A, Elissa N, Gomes B, Moreno M, Santolamazza F, Simard F, Vicente JL, Weetman D
  • Journal: Evolutionary Applications
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/24062800

The primary Afrotropical malaria mosquito vector Anopheles gambiae sensu stricto has a complex population structure. In west Africa, this species is split into two molecular forms and displays local and regional variation in chromosomal arrangements and behaviors.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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UID/04413/2025 - DOI: 10.54499/UID/04413/2025

UID/PRR/04413/2025 - DOI: 10.54499/UID/PRR/04413/2025

UID/PRR2/04413/2025 - DOI: 10.54499/UID/PRR2/04413/2025

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