Field, genetic, and modeling approaches show strong positive selection acting upon an insecticide resistance mutation in Anopheles gambiae s.s

• Authors: Barbosa S, Donnelly MJ, Egyir-Yawson A, Hastings I, Lynd A, Mitchell S, Weetman D, Pinto J
• Journal: Molecular Biology and Evolution
• Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Field%2C+genetic+and+modeling+approaches+show+strong+positive+selection+acting+upon+an+insecticide+resistance+mutation+in+Anopheles+gambiae+s.s

Alleles subject to strong, recent positive selection will be swept toward fixation together with contiguous sections of the genome. Whether the genomic signatures of such selection will be readily detectable in outbred wild populations is unclear. In this study, we employ haplotype diversity analysis to examine evidence for selective sweeps around knockdown resistance (kdr) mutations […]
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