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Home / Archives for Passero LF

The effect of ursolic acid on leishmania (Leishmania) amazonensis is related to programed cell death and presents therapeutic potential in experimental cutaneous leishmaniasis

  • Autores: Campos BL, Jesus JA, Kállas EG, Lago JH, Laurenti MD, Levy D, Passero LF, Rafael-Fernandes M, Ribeiro SP, Santos-Gomes G, Sessa DP, Silva MS, Yamamoto ES
  • Ano de Publicação: 2015
  • Journal: PLoS One
  • Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144946%20

Among neglected tropical diseases, leishmaniasis is one of the most important ones, affecting more than 12 million people worldwide. The available treatments are not well tolerated, and present diverse side effects, justifying the search for new therapeutic compounds. In the present study, the activity of ursolic acid (UA) and oleanolic acid (OA) were assayed in […]
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Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira baccata

  • Autores: Barreira L, Bruno de Sousa C, Campino L, Conserva GA, Custódio L, Gangadhar KN, Lago JH, Laurenti MD, Levy D, Morais TR, Passero LF, Pereira H, Uemi M, Varela J, Vizetto-Duarte C
  • Ano de Publicação: 2017
  • Journal: Experimental Parasitology
  • Link: https://www.sciencedirect.com/science/article/pii/S0014489417300371?via%3Dihub%20

The development of novel drugs for the treatment of leishmaniases continues to be crucial to overcome the severe impacts of these diseases on human and animal health. Several bioactivities have been described in extracts from macroalgae belonging to the Cystoseira genus. However, none of the studies has reported the chemical compounds responsible for the antileishmanial […]
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Histopathology, humoral and cellular immune response in the murine model of Leishmania (Viannia) shawi

  • Autores: Corbett CE, Laurenti MD, Marques C, Passero LF, Santos-Gomes G, Vale-Gato I
  • Journal: Parasitology International
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Histopathology%2C+humoral+and+cellular+immune+response+in+the+murine+model+of+Leishmania+(Viannia)+shawi

Leishmania (Viannia) shawi was recently characterized and few studies concerning modifications in cellular and humoral immune responses in experimental leishmaniasis have been conducted. In this work, immunopathological changes induced by L. shawi in chronically infected BALB/c mice were investigated.
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Analysis of the protective potential of antigens released by Leishmania (Viannia) shawi promastigotes.

  • Autores: Corbett CE, Laurenti MD, Marques C, Passero LF, Santos-Gomes G, Vale-Gato I
  • Journal: Archives of Dermatological Research
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Analysis+of+the+protective+potential+of+antigens+released+by+Leishmania+(Viannia)+shawi+promastigotes.

Leishmania (Viannia) shawi causes cutaneous lesions in humans. Parasite antigens conferring significant protection against American tegumentar leishmaniosis (ATL) might be important for the development of effective vaccine.
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New insights into neutrophil and Leishmania infantum in vitro immune interactions

  • Autores: Alexandre-Pires G, Correia I, Marques CS, Martins C, Rodrigues A, Rodrigues OR, Tomás AM, Vale-Gato I, Ferronha MH, Passero LF, Santos-Gomes G
  • Ano de Publicação: 2015
  • Journal: Comparative Immunology Microbiology and Infectious Diseases
  • Link: http://www.sciencedirect.com/science/article/pii/S0147957115000247

The interaction between polymorphonuclear leukocytes (PMN) or neutrophils and Leishmania became an interesting focus of research, since PMN turn out to be essential cells in transiently hosting the parasites. This study aims to evaluate whether L. infantum, the etiological agent of zoonotic visceral leishmaniasis, influences the in vitro functional activity of murine neutrophils. Phagocytosis, chemotaxis, […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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