The effect of ursolic acid on leishmania (Leishmania) amazonensis is related to programed cell death and presents therapeutic potential in experimental cutaneous leishmaniasis

Authors: Campos BL, Jesus JA, Kállas EG, Lago JH, Laurenti MD, Levy D, Passero LF, Rafael-Fernandes M, Ribeiro SP, Santos-Gomes G, Sessa DP, Silva MS, Yamamoto ES
Publication Year: 2015
Journal: PLoS One
Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144946%20

Among neglected tropical diseases, leishmaniasis is one of the most important ones, affecting more than 12 million people worldwide. The available treatments are not well tolerated, and present diverse side effects, justifying the search for new therapeutic compounds. In the present study, the activity of ursolic acid (UA) and oleanolic acid (OA) were assayed in […]
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Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira baccata

The development of novel drugs for the treatment of leishmaniases continues to be crucial to overcome the severe impacts of these diseases on human and animal health. Several bioactivities have been described in extracts from macroalgae belonging to the Cystoseira genus. However, none of the studies has reported the chemical compounds responsible for the antileishmanial […]
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The effect of ursolic acid on leishmania (Leishmania) amazonensis is related to programed cell death and presents therapeutic potential in experimental cutaneous leishmaniasis

Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira baccata

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