Competition between substrates of the efflux pump system of Salmonella enteritidis.
- Autores: Amaral L, Cerca P, Couto I, Martins A, Viveiros M
- Journal: In vivo
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Competition+between+substrates+of+the+efflux+pump+system+of+Salmonella+enteritidis
AIM:
To determine whether tetracycline competes with ethidium bromide (EB), used as substrate of efflux pumps, for extrusion by the efflux pump system of Salmonella enteritidis NCTC 13349 reference strain.
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Description of plasmid pSM52, harbouring the gene for the Smr efflux pump, and its involvement in resistance to biocides in a meticillin-resistant Staphylococcus aureus strain
- Autores: Amaral L, Costa SS, Couto I, Melo-Cristino J, Mourato C, Viveiros M
- Ano de Publicação: 2013
- Journal: International Journal of Antimicrobial Agents
- Link: http://www.ncbi.nlm.nih.gov/pubmed/23434536
Inhibition of quorum sensing and efflux pump system by trifluoromethyl ketone proton pump inhibitors.
- Autores: Amaral L, Armada A, Cerca P, Kawase M, Mior Ahmad Subki MA, Molnar J, Motohashi N, Savka MA, Szegedi E, Varga ZG
- Journal: In vivo
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Inhibition+of+Quorum+Sensing+and+Efflux+Pump+System+by+Trifluoromethyl+Ketone+Proton+Pump+Inhibitors
BACKGROUND:
One major microbiological problem is the widespread antibiotic resistance. There is an urgent need for new antibiotics and ways to treat multi-drug-resistant infections. Inhibition of bacterial quorum sensing (QS) systems could be an effective alternative in a smuch as they regulate a broad spectrum of cell functions, including, virulence factor production, biofilm organisation and motility. Influx and efflux bacterial systems involved in quorum sensing (QS) are known to depend on the proton motive force (PMF). Thus, a new series of 12 trifluoromethyl ketones (TFs) known to inhibit the PMF, was investigated for effects on the efflux pump of a QS responding bacterium, for its subsequent effect on the response to a QS signal and its direct inhibition of the response to a QS signal.
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Activity of fourteen new hydantoin compounds on the human ABCB1 efflux pump.
- Autores: Amaral L, Armada A, Dymek A, Handzlik J, Kiec-Kononowicz K, Martins A, Molnar J, Spengler G
- Journal: In vivo
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Activity+of+Fourteen+New+Hydantoin+Compounds+on+the+Human+ABCB1+Efflux+Pump
BACKGROUND:
Multidrug resistance (MDR) is one of the major concerns in the treatment of cancer and one of the major causes of therapy failure. The overexpression of an ABC transporter, the ABCB1, is often associated with MDR in cancer. Previously it was observed that hydantoin compounds can modulate the activity of the ABCB1 pump.
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