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Home / Archives for Varga ZG

Inhibition of quorum sensing and efflux pump system by trifluoromethyl ketone proton pump inhibitors.

  • Autores: Amaral L, Armada A, Cerca P, Kawase M, Mior Ahmad Subki MA, Molnar J, Motohashi N, Savka MA, Szegedi E, Varga ZG
  • Journal: In vivo
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Inhibition+of+Quorum+Sensing+and+Efflux+Pump+System+by+Trifluoromethyl+Ketone+Proton+Pump+Inhibitors

BACKGROUND:
One major microbiological problem is the widespread antibiotic resistance. There is an urgent need for new antibiotics and ways to treat multi-drug-resistant infections. Inhibition of bacterial quorum sensing (QS) systems could be an effective alternative in a smuch as they regulate a broad spectrum of cell functions, including, virulence factor production, biofilm organisation and motility. Influx and efflux bacterial systems involved in quorum sensing (QS) are known to depend on the proton motive force (PMF). Thus, a new series of 12 trifluoromethyl ketones (TFs) known to inhibit the PMF, was investigated for effects on the efflux pump of a QS responding bacterium, for its subsequent effect on the response to a QS signal and its direct inhibition of the response to a QS signal.
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Quorum Sensing Inhibition by Phenothiazines and Related Compounds.

  • Autores: Amaral L, Molnar J, Schelz Z, Szabó MA, Szegedi E, Varga ZG
  • Journal: Letters in Drug Design & Discovery
  • Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=22&SID=Y2ytOr2frNCuRlReLtM&page=1&doc=1

A quorum is the smallest number of people able to organize the decisions concerning functional activity. Similarly microbes use chemical signal molecules to make population size-dependent “decisions” by changing their gene regulations.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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