Identification of the plasmid-encoded qacA efflux pump gene in meticillin-resistant Staphylococcus aureus (MRSA) strain HPV107, a representative of the MRSA Iberian clone

Authors: Amaral L, Costa SS, Couto I, Martins A, Ntokou E, Pournaras S, Viveiros M
Journal: International Journal of Antimicrobial Agents
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Identification+of+the+plasmid+encoded+qacA+efflux+pump+gene+in+the+methicillin-resistant+Staphylococcus+aureus+(MRSA)+strain+HPV107%2C+a+representative+of+the+MRSA+Iberian+clone

Meticillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial bacterium for which prevention and control measures consist mainly of the application of biocides with antiseptic and disinfectant activity.
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Quinazoline derivatives are efficient chemosensitizers of antibiotic activity in Enterobacter aerogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa resistant strains

Authors: Adam E, Amaral L, Baitiche M, Chevalier J, Mahamoud A, Militaru A, Pagès JM, Pascu ML, Smarandache A, Viveiros M
Journal: International Journal of Antimicrobial Agents
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Quinazoline+derivatives+are+efficient+chemosensitizers+of+antibiotic+activity+in+Enterobacter+aerogenes%2C+Klebsiella+pneumoniae+and+Pseudomonas+aeruginosa+resistant+strains

Amongst the three series of quinazoline derivatives synthesised and studied in this work, some molecules increase the antibiotic susceptibility of Gram-negative bacteria presenting multidrug-resistant phenotypes.
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Identification of the plasmid-encoded qacA efflux pump gene in meticillin-resistant Staphylococcus aureus (MRSA) strain HPV107, a representative of the MRSA Iberian clone

Quinazoline derivatives are efficient chemosensitizers of antibiotic activity in Enterobacter aerogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa resistant strains

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