Direct modification of bioactive phenothiazines by exposure to laser radiation.

Authors: Amaral L, Andrei IR, Boni M, Fanning S, Martins A, Militaru A, Molnar J, Nastasa V, Pascu A, Pascu ML, Smarandache A, Staicu A, Viveiros M
Journal: Recent Patents on Anti-Infective Drug Discovery
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Direct+modification+of+bioactive+phenothiazines+by+exposure+to+laser+radiation.

Whereas exposure of combinations of a phenothiazine and bacterium to incoherent UV increases the activity of the phenothiazine, exposure of the phenothiazine alone does not yield an increase of its activity. Because the laser beam energy is greater than that produced by the incoherent UV sources, exposure of phenothiazines to specific lasers may yield molecules with altered activities over that of the unexposed parent.
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Quinazoline derivatives are efficient chemosensitizers of antibiotic activity in Enterobacter aerogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa resistant strains

Amongst the three series of quinazoline derivatives synthesised and studied in this work, some molecules increase the antibiotic susceptibility of Gram-negative bacteria presenting multidrug-resistant phenotypes.
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Direct modification of bioactive phenothiazines by exposure to laser radiation.

Quinazoline derivatives are efficient chemosensitizers of antibiotic activity in Enterobacter aerogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa resistant strains

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