GHTM

Global Health and Tropical Medicine

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Home / Archives for Kristiansen JE

Non-antibiotics reverse resistance of bacteria to antibiotics.

  • Authors: Amaral L, Kristiansen JE, Martins A, Thomsen VF, Viveiros M
  • Journal: In vivo
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/20952744

BACKGROUND: Most clinical isolates that exhibit a multi-drug resistant phenotype owe that resistance to over-expressed efflux pumps. Compounds that are efflux pump inhibitors (EPIs) reduce or reverse resistance to antibiotics to which the bacterial strain is initially resistant. We have evaluated non-antibiotics to reduce resistance of commonly encountered bacterial pathogens to antibiotics. MATERIALS AND METHODS: […]
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Phenothiazines, bacterial efflux pumps and targeting the macrophage for enhanced killing of intracellular XDRTB

  • Authors: Amaral L, Couto I, Dastidar S, Fanning S, Kristiansen JE, Martins A, Martins M, McCusker M, Molnar J, Pagès JM, Ramos J, Rodrigues L, Spengler G, Viveiros M
  • Journal: In vivo
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Phenothiazines%2C+bacterial+efflux+pumps+and+targeting+the+macrophage+for+enhanced+killing+of+intracellular+XDRTB

Phenothiazines have their primary effects on the plasma membrane of prokaryotes and eukaryotes. Among the components of the prokaryotic plasma membrane affected are efflux pumps, their energy sources, energy providing enzymes such as ATPases, and genes that regulate and code for permeability aspects of the bacterium.
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Activity of the efflux pump inhibitor SILA 421 against drug-resistant tuberculosis

  • Authors: Amaral L, Boeree MJ, Christensen JB, Hajos G, Kristiansen JE, Molnar J, Riedl Z, Simons SO, Van der Laan T, Van Ingen J, Van Soolingen D, Viveiros M
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23410790

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Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74

  • Authors: Amaral L, Chaki S, Christensen JB, Dasgupta A, Dastidar SG, Hendricks O, Kristiansen JE, Mukherjee S
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Thioridazine+protects+the+mouse+from+a+virulent+infection+by+Salmonella+enterica+serovar+Typhimurium+74

When administered to mice at doses of 100microg/mouse and 200microg/mouse, thioridazine (TDZ) significantly protected animals from the lethality produced by a virulent strain of Salmonella enterica serovar Typhimurium and reduced the number of bacteria retrieved from the spleen, liver and heart blood.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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